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GSK-3Beta-Dependent Activation of GEF-H1/ROCK Signaling Promotes LPS-Induced Lung Vascular Endothelial Barrier Dysfunction and Acute Lung Injury

The bacterial endotoxin or lipopolysaccharide (LPS) leads to the extensive vascular endothelial cells (EC) injury under septic conditions. Guanine nucleotide exchange factor-H1 (GEF-H1)/ROCK signaling not only involved in LPS-induced overexpression of pro-inflammatory mediator in ECs but also implic...

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Detalles Bibliográficos
Autores principales:	Yi, Lei, Huang, Xiaoqin, Guo, Feng, Zhou, Zengding, Chang, Mengling, Huan, Jingning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543036/ https://www.ncbi.nlm.nih.gov/pubmed/28824887 http://dx.doi.org/10.3389/fcimb.2017.00357

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