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HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
Cholinergic neuromodulation in the hippocampus controls the salience of background context memory acquired in the presence of elemental stimuli predicting an aversive reinforcement. With pharmacogenetic inhibition we here demonstrate that hilar perforant path-associated (HIPP) cells of the dentate g...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543060/ https://www.ncbi.nlm.nih.gov/pubmed/28775269 http://dx.doi.org/10.1038/s41467-017-00205-3 |
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author | Raza, Syed Ahsan Albrecht, Anne Çalışkan, Gürsel Müller, Bettina Demiray, Yunus Emre Ludewig, Susann Meis, Susanne Faber, Nicolai Hartig, Roland Schraven, Burkhart Lessmann, Volkmar Schwegler, Herbert Stork, Oliver |
author_facet | Raza, Syed Ahsan Albrecht, Anne Çalışkan, Gürsel Müller, Bettina Demiray, Yunus Emre Ludewig, Susann Meis, Susanne Faber, Nicolai Hartig, Roland Schraven, Burkhart Lessmann, Volkmar Schwegler, Herbert Stork, Oliver |
author_sort | Raza, Syed Ahsan |
collection | PubMed |
description | Cholinergic neuromodulation in the hippocampus controls the salience of background context memory acquired in the presence of elemental stimuli predicting an aversive reinforcement. With pharmacogenetic inhibition we here demonstrate that hilar perforant path-associated (HIPP) cells of the dentate gyrus mediate the devaluation of background context memory during Pavlovian fear conditioning. The salience adjustment is sensitive to reduction of hilar neuropeptide Y (NPY) expression via dominant negative CREB expression in HIPP cells and to acute blockage of NPY-Y1 receptors in the dentate gyrus during conditioning. We show that NPY transmission and HIPP cell activity contribute to inhibitory effects of acetylcholine in the dentate gyrus and that M1 muscarinic receptors mediate the cholinergic activation of HIPP cells as well as their control of background context salience. Our data provide evidence for a peptidergic local circuit in the dentate gyrus that mediates the cholinergic encoding of background context salience during fear memory acquisition. |
format | Online Article Text |
id | pubmed-5543060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55430602017-08-09 HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience Raza, Syed Ahsan Albrecht, Anne Çalışkan, Gürsel Müller, Bettina Demiray, Yunus Emre Ludewig, Susann Meis, Susanne Faber, Nicolai Hartig, Roland Schraven, Burkhart Lessmann, Volkmar Schwegler, Herbert Stork, Oliver Nat Commun Article Cholinergic neuromodulation in the hippocampus controls the salience of background context memory acquired in the presence of elemental stimuli predicting an aversive reinforcement. With pharmacogenetic inhibition we here demonstrate that hilar perforant path-associated (HIPP) cells of the dentate gyrus mediate the devaluation of background context memory during Pavlovian fear conditioning. The salience adjustment is sensitive to reduction of hilar neuropeptide Y (NPY) expression via dominant negative CREB expression in HIPP cells and to acute blockage of NPY-Y1 receptors in the dentate gyrus during conditioning. We show that NPY transmission and HIPP cell activity contribute to inhibitory effects of acetylcholine in the dentate gyrus and that M1 muscarinic receptors mediate the cholinergic activation of HIPP cells as well as their control of background context salience. Our data provide evidence for a peptidergic local circuit in the dentate gyrus that mediates the cholinergic encoding of background context salience during fear memory acquisition. Nature Publishing Group UK 2017-08-04 /pmc/articles/PMC5543060/ /pubmed/28775269 http://dx.doi.org/10.1038/s41467-017-00205-3 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Raza, Syed Ahsan Albrecht, Anne Çalışkan, Gürsel Müller, Bettina Demiray, Yunus Emre Ludewig, Susann Meis, Susanne Faber, Nicolai Hartig, Roland Schraven, Burkhart Lessmann, Volkmar Schwegler, Herbert Stork, Oliver HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience |
title | HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience |
title_full | HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience |
title_fullStr | HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience |
title_full_unstemmed | HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience |
title_short | HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience |
title_sort | hipp neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543060/ https://www.ncbi.nlm.nih.gov/pubmed/28775269 http://dx.doi.org/10.1038/s41467-017-00205-3 |
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