In silico model of the human ClC-Kb chloride channel: pore mapping, biostructural pathology and drug screening

The human ClC-Kb channel plays a key role in exporting chloride ions from the cytosol and is known to be involved in Bartter syndrome type 3 when its permeation capacity is decreased. The ClC-Kb channel has been recently proposed as a potential therapeutic target to treat hypertension. In order to g...

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Detalles Bibliográficos
Autores principales: Louet, Maxime, Bitam, Sara, Bakouh, Naziha, Bignon, Yohan, Planelles, Gabrielle, Lagorce, David, Miteva, Maria A., Eladari, Dominique, Teulon, Jacques, Villoutreix, Bruno O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543074/
https://www.ncbi.nlm.nih.gov/pubmed/28775266
http://dx.doi.org/10.1038/s41598-017-07794-5

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