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Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder (ADHD) is the most common neuropsychiatric disorder in childhood and is characterized by a delay of cortical maturation in frontal regions. In order to investigate interference control, which is a key function of frontal areas, a functional MRI study was cond...

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Autores principales: Zamorano, Francisco, Billeke, Pablo, Kausel, Leonie, Larrain, Josefina, Stecher, Ximena, Hurtado, Jose M., López, Vladimir, Carrasco, Ximena, Aboitiz, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543103/
https://www.ncbi.nlm.nih.gov/pubmed/28775285
http://dx.doi.org/10.1038/s41598-017-07681-z
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author Zamorano, Francisco
Billeke, Pablo
Kausel, Leonie
Larrain, Josefina
Stecher, Ximena
Hurtado, Jose M.
López, Vladimir
Carrasco, Ximena
Aboitiz, Francisco
author_facet Zamorano, Francisco
Billeke, Pablo
Kausel, Leonie
Larrain, Josefina
Stecher, Ximena
Hurtado, Jose M.
López, Vladimir
Carrasco, Ximena
Aboitiz, Francisco
author_sort Zamorano, Francisco
collection PubMed
description Attention Deficit Hyperactivity Disorder (ADHD) is the most common neuropsychiatric disorder in childhood and is characterized by a delay of cortical maturation in frontal regions. In order to investigate interference control, which is a key function of frontal areas, a functional MRI study was conducted on 17 ADHD boys and 17 typically developing (TD) boys, while solving the multi source interference task (MSIT). This task consists of two conditions, a “congruent condition” and an “incongruent condition”. The latter requires to inhibit information that interferes with task-relevant stimuli. Behavioral results showed that ADHD subjects committed more errors than TD children. In addition, TD children presented a larger MSIT effect -a greater difference in reaction times between the incongruent and the congruent conditions- than ADHD children. Associated to the MSIT effect, neuroimaging results showed a significant enhancement in the activation of the right lateral prefrontal cortex (rlPFC) in ADHD than in TD subjects. Finally, ADHD subjects presented greater functional connectivity between rlPFC and bilateral orbitofrontal cortex than the TD group. This difference in connectivity correlated with worse performance in both groups. Our results could reflect a compensatory strategy of ADHD children resulting from their effort to maintain an adequate performance during MSIT.
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spelling pubmed-55431032017-08-07 Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder Zamorano, Francisco Billeke, Pablo Kausel, Leonie Larrain, Josefina Stecher, Ximena Hurtado, Jose M. López, Vladimir Carrasco, Ximena Aboitiz, Francisco Sci Rep Article Attention Deficit Hyperactivity Disorder (ADHD) is the most common neuropsychiatric disorder in childhood and is characterized by a delay of cortical maturation in frontal regions. In order to investigate interference control, which is a key function of frontal areas, a functional MRI study was conducted on 17 ADHD boys and 17 typically developing (TD) boys, while solving the multi source interference task (MSIT). This task consists of two conditions, a “congruent condition” and an “incongruent condition”. The latter requires to inhibit information that interferes with task-relevant stimuli. Behavioral results showed that ADHD subjects committed more errors than TD children. In addition, TD children presented a larger MSIT effect -a greater difference in reaction times between the incongruent and the congruent conditions- than ADHD children. Associated to the MSIT effect, neuroimaging results showed a significant enhancement in the activation of the right lateral prefrontal cortex (rlPFC) in ADHD than in TD subjects. Finally, ADHD subjects presented greater functional connectivity between rlPFC and bilateral orbitofrontal cortex than the TD group. This difference in connectivity correlated with worse performance in both groups. Our results could reflect a compensatory strategy of ADHD children resulting from their effort to maintain an adequate performance during MSIT. Nature Publishing Group UK 2017-08-03 /pmc/articles/PMC5543103/ /pubmed/28775285 http://dx.doi.org/10.1038/s41598-017-07681-z Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zamorano, Francisco
Billeke, Pablo
Kausel, Leonie
Larrain, Josefina
Stecher, Ximena
Hurtado, Jose M.
López, Vladimir
Carrasco, Ximena
Aboitiz, Francisco
Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder
title Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder
title_full Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder
title_fullStr Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder
title_full_unstemmed Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder
title_short Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder
title_sort lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in attention deficit hyperactivity disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543103/
https://www.ncbi.nlm.nih.gov/pubmed/28775285
http://dx.doi.org/10.1038/s41598-017-07681-z
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