Selection and characterization of DNA aptamer against glucagon receptor by cell-SELEX

Excessive secretion of glucagon, a functional insulin antagonist, significantly contributes to hyperglycemia. Glucagon exerts its physiological functions through activation of the glucagon receptor (GCGR). Inhibition of GCGR activity represents a potential therapeutic approach for reducing excess gl...

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Detalles Bibliográficos
Autores principales: Wang, Guodong, Liu, Jun, Chen, Ke, Xu, Yiling, Liu, Bo, Liao, Jie, Zhu, Lei, Hu, Xiaoxiao, Li, Jianglin, Pu, Ying, Zhong, Wen, Fu, Ting, Liu, Huixia, Tan, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543139/
https://www.ncbi.nlm.nih.gov/pubmed/28775305
http://dx.doi.org/10.1038/s41598-017-05840-w

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