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Mutations Driving Airborne Transmission of A/H5N1 Virus in Mammals Cause Substantial Attenuation in Chickens only when combined

A/H5N1 influenza viruses pose a threat to human and animal health. A fully avian A/H5N1 influenza virus was previously shown to acquire airborne transmissibility between ferrets upon accumulation of five or six substitutions that affected three traits: polymerase activity, hemagglutinin stability an...

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Detalles Bibliográficos
Autores principales:	Richard, Mathilde, Herfst, Sander, van den Brand, Judith M. A., de Meulder, Dennis, Lexmond, Pascal, Bestebroer, Theo M., Fouchier, Ron A. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543172/ https://www.ncbi.nlm.nih.gov/pubmed/28775271 http://dx.doi.org/10.1038/s41598-017-07000-6

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