A novel missense mutation of Mip causes semi-dominant cataracts in the Nat mouse

Major intrinsic protein of lens fiber (MIP) is one of the proteins essential for maintaining lens transparency while also contributing to dominant cataracts in humans. The Nodai cataract (Nat) mice harbor a spontaneous mutation in Mip and develop early-onset nuclear cataracts. The Nat mutation is a...

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Detalles Bibliográficos
Autores principales: Takahashi, Gou, Hasegawa, Sayaka, Fukutomi, Yukiko, Harada, Chihiro, Furugori, Masamune, Seki, Yuta, Kikkawa, Yoshiaki, Wada, Kenta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2017
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543248/
https://www.ncbi.nlm.nih.gov/pubmed/28442635
http://dx.doi.org/10.1538/expanim.17-0012

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