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Developmental and Functional Control of Natural Killer Cells by Cytokines
Natural killer (NK) cells are effective in combating infections and tumors and as such are tempting for adoptive transfer therapy. However, they are not homogeneous but can be divided into three main subsets, including cytotoxic, tolerant, and regulatory NK cells, with disparate phenotypes and funct...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543290/ https://www.ncbi.nlm.nih.gov/pubmed/28824650 http://dx.doi.org/10.3389/fimmu.2017.00930 |
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author | Wu, Yang Tian, Zhigang Wei, Haiming |
author_facet | Wu, Yang Tian, Zhigang Wei, Haiming |
author_sort | Wu, Yang |
collection | PubMed |
description | Natural killer (NK) cells are effective in combating infections and tumors and as such are tempting for adoptive transfer therapy. However, they are not homogeneous but can be divided into three main subsets, including cytotoxic, tolerant, and regulatory NK cells, with disparate phenotypes and functions in diverse tissues. The development and functions of such NK cells are controlled by various cytokines, such as fms-like tyrosine kinase 3 ligand (FL), kit ligand (KL), interleukin (IL)-3, IL-10, IL-12, IL-18, transforming growth factor-β, and common-γ chain family cytokines, which operate at different stages by regulating distinct signaling pathways. Nevertheless, the specific roles of each cytokine that regulates NK cell development or that shapes different NK cell functions remain unclear. In this review, we attempt to describe the characteristics of each cytokine and the existing protocols to expand NK cells using different combinations of cytokines and feeder cells. A comprehensive understanding of the role of cytokines in NK cell development and function will aid the generation of better efficacy for adoptive NK cell treatment. |
format | Online Article Text |
id | pubmed-5543290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55432902017-08-18 Developmental and Functional Control of Natural Killer Cells by Cytokines Wu, Yang Tian, Zhigang Wei, Haiming Front Immunol Immunology Natural killer (NK) cells are effective in combating infections and tumors and as such are tempting for adoptive transfer therapy. However, they are not homogeneous but can be divided into three main subsets, including cytotoxic, tolerant, and regulatory NK cells, with disparate phenotypes and functions in diverse tissues. The development and functions of such NK cells are controlled by various cytokines, such as fms-like tyrosine kinase 3 ligand (FL), kit ligand (KL), interleukin (IL)-3, IL-10, IL-12, IL-18, transforming growth factor-β, and common-γ chain family cytokines, which operate at different stages by regulating distinct signaling pathways. Nevertheless, the specific roles of each cytokine that regulates NK cell development or that shapes different NK cell functions remain unclear. In this review, we attempt to describe the characteristics of each cytokine and the existing protocols to expand NK cells using different combinations of cytokines and feeder cells. A comprehensive understanding of the role of cytokines in NK cell development and function will aid the generation of better efficacy for adoptive NK cell treatment. Frontiers Media S.A. 2017-08-04 /pmc/articles/PMC5543290/ /pubmed/28824650 http://dx.doi.org/10.3389/fimmu.2017.00930 Text en Copyright © 2017 Wu, Tian and Wei. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wu, Yang Tian, Zhigang Wei, Haiming Developmental and Functional Control of Natural Killer Cells by Cytokines |
title | Developmental and Functional Control of Natural Killer Cells by Cytokines |
title_full | Developmental and Functional Control of Natural Killer Cells by Cytokines |
title_fullStr | Developmental and Functional Control of Natural Killer Cells by Cytokines |
title_full_unstemmed | Developmental and Functional Control of Natural Killer Cells by Cytokines |
title_short | Developmental and Functional Control of Natural Killer Cells by Cytokines |
title_sort | developmental and functional control of natural killer cells by cytokines |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543290/ https://www.ncbi.nlm.nih.gov/pubmed/28824650 http://dx.doi.org/10.3389/fimmu.2017.00930 |
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