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Clinical Trials.Gov: A Topical Analyses
ClinicalTrials.gov was established as a web-based registry for clinical trials of human participants in 2000. Mandatory registration started in 2008. Given more than a decade of registered trials, it’s important to understand the “topic” areas and their evolution over time from this resource. This i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Medical Informatics Association
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543348/ https://www.ncbi.nlm.nih.gov/pubmed/28815102 |
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author | Anand, Vibha Cahan, Amos Ghosh, Soumya |
author_facet | Anand, Vibha Cahan, Amos Ghosh, Soumya |
author_sort | Anand, Vibha |
collection | PubMed |
description | ClinicalTrials.gov was established as a web-based registry for clinical trials of human participants in 2000. Mandatory registration started in 2008. Given more than a decade of registered trials, it’s important to understand the “topic” areas and their evolution over time from this resource. This information may help in identifying current knowledge gaps. We use dynamic topic model (DTM) methods to discover topics and their evolution over last 17 years. Our model suggests that there are disease or organ specific trials such as ‘Cardiovascular disorders’, Heart & Brain conditions’, or ‘Breast & Prostate cancer’ as well as trials registered for general health. General health trials are less likely to be FDA regulated, but both health and pain management, as well as surgical, heart, and brain trials have upward trend in recent years while advanced cancer trials have downward trended. Our model derives unique insights from metadata associated with each topic area. |
format | Online Article Text |
id | pubmed-5543348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | American Medical Informatics Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-55433482017-08-16 Clinical Trials.Gov: A Topical Analyses Anand, Vibha Cahan, Amos Ghosh, Soumya AMIA Jt Summits Transl Sci Proc Articles ClinicalTrials.gov was established as a web-based registry for clinical trials of human participants in 2000. Mandatory registration started in 2008. Given more than a decade of registered trials, it’s important to understand the “topic” areas and their evolution over time from this resource. This information may help in identifying current knowledge gaps. We use dynamic topic model (DTM) methods to discover topics and their evolution over last 17 years. Our model suggests that there are disease or organ specific trials such as ‘Cardiovascular disorders’, Heart & Brain conditions’, or ‘Breast & Prostate cancer’ as well as trials registered for general health. General health trials are less likely to be FDA regulated, but both health and pain management, as well as surgical, heart, and brain trials have upward trend in recent years while advanced cancer trials have downward trended. Our model derives unique insights from metadata associated with each topic area. American Medical Informatics Association 2017-07-26 /pmc/articles/PMC5543348/ /pubmed/28815102 Text en ©2017 AMIA - All rights reserved. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose |
spellingShingle | Articles Anand, Vibha Cahan, Amos Ghosh, Soumya Clinical Trials.Gov: A Topical Analyses |
title | Clinical Trials.Gov: A Topical Analyses |
title_full | Clinical Trials.Gov: A Topical Analyses |
title_fullStr | Clinical Trials.Gov: A Topical Analyses |
title_full_unstemmed | Clinical Trials.Gov: A Topical Analyses |
title_short | Clinical Trials.Gov: A Topical Analyses |
title_sort | clinical trials.gov: a topical analyses |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543348/ https://www.ncbi.nlm.nih.gov/pubmed/28815102 |
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