Cargando…

Clinical Trials.Gov: A Topical Analyses

ClinicalTrials.gov was established as a web-based registry for clinical trials of human participants in 2000. Mandatory registration started in 2008. Given more than a decade of registered trials, it’s important to understand the “topic” areas and their evolution over time from this resource. This i...

Descripción completa

Detalles Bibliográficos
Autores principales: Anand, Vibha, Cahan, Amos, Ghosh, Soumya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Informatics Association 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543348/
https://www.ncbi.nlm.nih.gov/pubmed/28815102
_version_ 1783255132593455104
author Anand, Vibha
Cahan, Amos
Ghosh, Soumya
author_facet Anand, Vibha
Cahan, Amos
Ghosh, Soumya
author_sort Anand, Vibha
collection PubMed
description ClinicalTrials.gov was established as a web-based registry for clinical trials of human participants in 2000. Mandatory registration started in 2008. Given more than a decade of registered trials, it’s important to understand the “topic” areas and their evolution over time from this resource. This information may help in identifying current knowledge gaps. We use dynamic topic model (DTM) methods to discover topics and their evolution over last 17 years. Our model suggests that there are disease or organ specific trials such as ‘Cardiovascular disorders’, Heart & Brain conditions’, or ‘Breast & Prostate cancer’ as well as trials registered for general health. General health trials are less likely to be FDA regulated, but both health and pain management, as well as surgical, heart, and brain trials have upward trend in recent years while advanced cancer trials have downward trended. Our model derives unique insights from metadata associated with each topic area.
format Online
Article
Text
id pubmed-5543348
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher American Medical Informatics Association
record_format MEDLINE/PubMed
spelling pubmed-55433482017-08-16 Clinical Trials.Gov: A Topical Analyses Anand, Vibha Cahan, Amos Ghosh, Soumya AMIA Jt Summits Transl Sci Proc Articles ClinicalTrials.gov was established as a web-based registry for clinical trials of human participants in 2000. Mandatory registration started in 2008. Given more than a decade of registered trials, it’s important to understand the “topic” areas and their evolution over time from this resource. This information may help in identifying current knowledge gaps. We use dynamic topic model (DTM) methods to discover topics and their evolution over last 17 years. Our model suggests that there are disease or organ specific trials such as ‘Cardiovascular disorders’, Heart & Brain conditions’, or ‘Breast & Prostate cancer’ as well as trials registered for general health. General health trials are less likely to be FDA regulated, but both health and pain management, as well as surgical, heart, and brain trials have upward trend in recent years while advanced cancer trials have downward trended. Our model derives unique insights from metadata associated with each topic area. American Medical Informatics Association 2017-07-26 /pmc/articles/PMC5543348/ /pubmed/28815102 Text en ©2017 AMIA - All rights reserved. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose
spellingShingle Articles
Anand, Vibha
Cahan, Amos
Ghosh, Soumya
Clinical Trials.Gov: A Topical Analyses
title Clinical Trials.Gov: A Topical Analyses
title_full Clinical Trials.Gov: A Topical Analyses
title_fullStr Clinical Trials.Gov: A Topical Analyses
title_full_unstemmed Clinical Trials.Gov: A Topical Analyses
title_short Clinical Trials.Gov: A Topical Analyses
title_sort clinical trials.gov: a topical analyses
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543348/
https://www.ncbi.nlm.nih.gov/pubmed/28815102
work_keys_str_mv AT anandvibha clinicaltrialsgovatopicalanalyses
AT cahanamos clinicaltrialsgovatopicalanalyses
AT ghoshsoumya clinicaltrialsgovatopicalanalyses