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Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening
[Image: see text] Proteins typically interact with multiple binding partners, and often different parts of their surfaces are employed to establish these protein–protein interactions (PPIs). Members of the class of 14-3-3 adapter proteins bind to several hundred other proteins in the cell. Multiple...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543393/ https://www.ncbi.nlm.nih.gov/pubmed/28681606 http://dx.doi.org/10.1021/acs.biochem.7b00153 |