Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer’s disease

BACKGROUND: Tau is an axon-enriched protein that binds to and stabilizes microtubules, and hence plays a crucial role in neuronal function. In Alzheimer’s disease (AD), pathological tau accumulation correlates with cognitive decline. Substantial visual deficits are found in individuals affected by A...

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Detalles Bibliográficos
Autores principales: Chiasseu, Marius, Alarcon-Martinez, Luis, Belforte, Nicolas, Quintero, Heberto, Dotigny, Florence, Destroismaisons, Laurie, Vande Velde, Christine, Panayi, Fany, Louis, Caroline, Di Polo, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543446/
https://www.ncbi.nlm.nih.gov/pubmed/28774322
http://dx.doi.org/10.1186/s13024-017-0199-3

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