Two separate effects contribute to regulatory T cell defect in systemic lupus erythematosus patients and their unaffected relatives

Forkhead box P3 (FoxP3)(+) regulatory T cells (T(regs)) are functionally deficient in systemic lupus erythematosus (SLE), characterized by reduced surface CD25 [the interleukin (IL)‐2 receptor alpha chain]. Low‐dose IL‐2 therapy is a promising current approach to correct this defect. To elucidate th...

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Detalles Bibliográficos
Autores principales: Costa, N., Marques, O., Godinho, S. I., Carvalho, C., Leal, B., Figueiredo, A. M., Vasconcelos, C., Marinho, A., Moraes‐Fontes, M. F., Gomes da Costa, A., Ponte, C., Campanilho‐Marques, R., Cóias, T., Martins, A. R., Viana, J. F., Lima, M., Martins, B., Fesel, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543470/
https://www.ncbi.nlm.nih.gov/pubmed/28542701
http://dx.doi.org/10.1111/cei.12991

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