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A cross-sectional survey of soil-transmitted helminthiases in two Myanmar villages receiving mass drug administration: epidemiology of infection with a focus on adults

BACKGROUND: Soil-transmitted helminths (STH) are still highly prevalent in southeast Asia. The country of Myanmar has had ongoing mass drug administration (MDA) programmes since 2003 in an attempt to control STH and reduce STH-related morbidities. Whilst the MDA programmes have reported high nationw...

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Autores principales: Dunn, Julia C., Bettis, Alison A., Wyine, Nay Yee, Lwin, Aye Moe Moe, Lwin, Soe Thiha, Su, Khine Khine, Sein, Myint Myint, Tun, Aung, Maung, Nay Soe, Anderson, Roy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543579/
https://www.ncbi.nlm.nih.gov/pubmed/28778217
http://dx.doi.org/10.1186/s13071-017-2306-2
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author Dunn, Julia C.
Bettis, Alison A.
Wyine, Nay Yee
Lwin, Aye Moe Moe
Lwin, Soe Thiha
Su, Khine Khine
Sein, Myint Myint
Tun, Aung
Maung, Nay Soe
Anderson, Roy M.
author_facet Dunn, Julia C.
Bettis, Alison A.
Wyine, Nay Yee
Lwin, Aye Moe Moe
Lwin, Soe Thiha
Su, Khine Khine
Sein, Myint Myint
Tun, Aung
Maung, Nay Soe
Anderson, Roy M.
author_sort Dunn, Julia C.
collection PubMed
description BACKGROUND: Soil-transmitted helminths (STH) are still highly prevalent in southeast Asia. The country of Myanmar has had ongoing mass drug administration (MDA) programmes since 2003 in an attempt to control STH and reduce STH-related morbidities. Whilst the MDA programmes have reported high nationwide coverage, there have been no epidemiological surveys that included measurements from adults. This paper details three cross-sectional surveys that took place over the course of a year in two villages endemic for STH and receiving MDA in lower Myanmar. RESULTS: At baseline, 27.81% of participants were infected with at least one type of STH. The most prevalent STH was Trichuris trichiura (18.12%) followed by hookworm (8.71%) and Ascaris lumbricoides (5.34%). Most infections were of low intensity, measured by eggs per gram of faeces (EPG). Gender stratification revealed that A. lumbricoides prevalence was significantly higher in females, whereas hookworm prevalence was significantly higher in males. The distribution of EPG in the study sample was highly overdispersed, suggesting that most people release few eggs whereas a few people release many eggs. Adults harbour a major proportion of the overall STH burden; 65.15% of STH infections were harboured by adults. CONCLUSIONS: STH infection remains at medium prevalence in the study villages despite past and recent MDA. Recorded prevalence of STH in school-aged children has not substantially decreased since the last monitoring and evaluation activities in Myanmar in 2013. Analyses suggest that adults are a major contributor to the total STH prevalence and EPG burden, probably perpetuating transmission. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13071-017-2306-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-55435792017-08-07 A cross-sectional survey of soil-transmitted helminthiases in two Myanmar villages receiving mass drug administration: epidemiology of infection with a focus on adults Dunn, Julia C. Bettis, Alison A. Wyine, Nay Yee Lwin, Aye Moe Moe Lwin, Soe Thiha Su, Khine Khine Sein, Myint Myint Tun, Aung Maung, Nay Soe Anderson, Roy M. Parasit Vectors Research Article BACKGROUND: Soil-transmitted helminths (STH) are still highly prevalent in southeast Asia. The country of Myanmar has had ongoing mass drug administration (MDA) programmes since 2003 in an attempt to control STH and reduce STH-related morbidities. Whilst the MDA programmes have reported high nationwide coverage, there have been no epidemiological surveys that included measurements from adults. This paper details three cross-sectional surveys that took place over the course of a year in two villages endemic for STH and receiving MDA in lower Myanmar. RESULTS: At baseline, 27.81% of participants were infected with at least one type of STH. The most prevalent STH was Trichuris trichiura (18.12%) followed by hookworm (8.71%) and Ascaris lumbricoides (5.34%). Most infections were of low intensity, measured by eggs per gram of faeces (EPG). Gender stratification revealed that A. lumbricoides prevalence was significantly higher in females, whereas hookworm prevalence was significantly higher in males. The distribution of EPG in the study sample was highly overdispersed, suggesting that most people release few eggs whereas a few people release many eggs. Adults harbour a major proportion of the overall STH burden; 65.15% of STH infections were harboured by adults. CONCLUSIONS: STH infection remains at medium prevalence in the study villages despite past and recent MDA. Recorded prevalence of STH in school-aged children has not substantially decreased since the last monitoring and evaluation activities in Myanmar in 2013. Analyses suggest that adults are a major contributor to the total STH prevalence and EPG burden, probably perpetuating transmission. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13071-017-2306-2) contains supplementary material, which is available to authorized users. BioMed Central 2017-08-04 /pmc/articles/PMC5543579/ /pubmed/28778217 http://dx.doi.org/10.1186/s13071-017-2306-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Dunn, Julia C.
Bettis, Alison A.
Wyine, Nay Yee
Lwin, Aye Moe Moe
Lwin, Soe Thiha
Su, Khine Khine
Sein, Myint Myint
Tun, Aung
Maung, Nay Soe
Anderson, Roy M.
A cross-sectional survey of soil-transmitted helminthiases in two Myanmar villages receiving mass drug administration: epidemiology of infection with a focus on adults
title A cross-sectional survey of soil-transmitted helminthiases in two Myanmar villages receiving mass drug administration: epidemiology of infection with a focus on adults
title_full A cross-sectional survey of soil-transmitted helminthiases in two Myanmar villages receiving mass drug administration: epidemiology of infection with a focus on adults
title_fullStr A cross-sectional survey of soil-transmitted helminthiases in two Myanmar villages receiving mass drug administration: epidemiology of infection with a focus on adults
title_full_unstemmed A cross-sectional survey of soil-transmitted helminthiases in two Myanmar villages receiving mass drug administration: epidemiology of infection with a focus on adults
title_short A cross-sectional survey of soil-transmitted helminthiases in two Myanmar villages receiving mass drug administration: epidemiology of infection with a focus on adults
title_sort cross-sectional survey of soil-transmitted helminthiases in two myanmar villages receiving mass drug administration: epidemiology of infection with a focus on adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543579/
https://www.ncbi.nlm.nih.gov/pubmed/28778217
http://dx.doi.org/10.1186/s13071-017-2306-2
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