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Analysis of Genetic Variation of Two NADC30-like Strains of Porcine Reproductive and Respiratory Syndrome Virus in China

BACKGROUND: NADC30-like strains of porcine reproductive and respiratory syndrome virus first appeared in Chinese swine herds in 2012. OBJECTIVE AND METHOD: To explore the possible genetic diversity of these strains, we sequenced and analyzed the complete genomes of two NADC30-like strains. These iso...

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Detalles Bibliográficos
Autores principales: Zhou, Zhi, Wu, Jiajun, Zhang, Shuo, Hou, Bo, Han, Tao, Wang, Jing, Xu, Qi, Wang, Dongyue, Liu, Yinyi, Xin, Shengpeng, Zhai, Xinyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543627/
https://www.ncbi.nlm.nih.gov/pubmed/28839509
http://dx.doi.org/10.2174/1874357901711010090
Descripción
Sumario:BACKGROUND: NADC30-like strains of porcine reproductive and respiratory syndrome virus first appeared in Chinese swine herds in 2012. OBJECTIVE AND METHOD: To explore the possible genetic diversity of these strains, we sequenced and analyzed the complete genomes of two NADC30-like strains. These isolates shared 95.4% homology with NADC30. RESULT: The two strains displayed a discontinuous deletion of 131 amino acids in NSP2, mutations of amino acids in GP3 and GP5, and a 3-nucleotide deletion in the 3′ untranslated region. Phylogenetic analysis showed that the two isolates formed a new branch and clustered in a subgroup with NADC30 isolates from North America. CONCLUSION: We conclude that the above two NADC30-like strains may have been introduced from North America to China, where they acquired new genetic diversity.