Cargando…

Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A(2A) receptor-induced SDF-1/CXCR4/PI3K/AKT signaling

BACKGROUND: Baicalin, an important flavonoid in Scutellaria baicalensis Georgi extracts, exerts a variety of pharmacological effects. In this study, we explored the effects of baicalin on chronic hypoxia-induced pulmonary arterial hypertension (PAH) and investigated the mechanism underlying these ef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Xiaoying, Wu, Peiliang, Huang, Feifei, Xu, Min, Chen, Mayun, Huang, Kate, Li, Guo-ping, Xu, Manhuan, Yao, Dan, Wang, Liangxing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543745/ https://www.ncbi.nlm.nih.gov/pubmed/28774332 http://dx.doi.org/10.1186/s12929-017-0359-3

Ejemplares similares

Baicalin attenuates bleomycin-induced pulmonary fibrosis via adenosine A2a receptor related TGF-β1-induced ERK1/2 signaling pathway
por: Huang, Xiaoying, et al.
Publicado: (2016)

Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9
por: Yan, Shuangquan, et al.
Publicado: (2016)

Baicalin promotes apoptosis and inhibits proliferation and migration of hypoxia-induced pulmonary artery smooth muscle cells by up-regulating A2a receptor via the SDF-1/CXCR4 signaling pathway
por: Huang, Xiaoying, et al.
Publicado: (2018)

Correction: Baicalin promotes apoptosis and inhibits proliferation and migration of hypoxia-induced pulmonary artery smooth muscle cells by up-regulating A2a receptor via the SDF-1/CXCR4 signaling pathway
por: Huang, Xiaoying, et al.
Publicado: (2023)

Effects of baicalin on collagen Ι and collagen ΙΙΙ expression in pulmonary arteries of rats with hypoxic pulmonary hypertension
por: LIU, PANPAN, et al.
Publicado: (2015)

Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway
por: Gui, Di, et al.
Publicado: (2017)

Effect of asiaticoside on endothelial cells in hypoxia-induced pulmonary hypertension
por: Wang, Xiaobing, et al.
Publicado: (2018)

Dihydroartemisinin Attenuates Hypoxia-Induced Pulmonary Hypertension Through the ELAVL2/miR-503/PI3K/AKT Axis
por: Cai, Haijian, et al.
Publicado: (2022)

CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1α
por: Esencay, Mine, et al.
Publicado: (2013)

SDF-1α/CXCR4 Signaling in Lipid Rafts Induces Platelet Aggregation via PI3 Kinase-Dependent Akt Phosphorylation
por: Ohtsuka, Hiroko, et al.
Publicado: (2017)

The Role of SDF-1α-CXCR4/CXCR7 in Migration of Human Periodontal Ligament Stem Cells
por: Xu, Jialei, et al.
Publicado: (2023)

SDF1/CXCR4 axis facilitates the angiogenesis via activating the PI3K/AKT pathway in degenerated discs
por: Zhang, Hanxiang, et al.
Publicado: (2020)

Crosstalk between SDF-1/CXCR4 and SDF-1/CXCR7 in cardiac stem cell migration
por: Chen, Dong, et al.
Publicado: (2015)

CXCL12/SDF-1 and CXCR4
por: Nagasawa, Takashi
Publicado: (2015)

Baicalin attenuates liver hypoxia/reoxygenation injury by inducing autophagy
por: Liu, Feng, et al.
Publicado: (2018)

Baicalin inhibits growth and induces apoptosis of human osteosarcoma cells by suppressing the AKT pathway
por: Liu, Yu, et al.
Publicado: (2019)

Author Correction: Crosstalk between SDF-1/CXCR4 and SDF-1/CXCR7 in cardiac stem cell migration
por: Chen, Dong, et al.
Publicado: (2022)

CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression
por: Sun, Xiaojuan, et al.
Publicado: (2010)

Breast cancer stromal fibroblasts promote the generation of CD44(+)CD24(- )cells through SDF-1/CXCR4 interaction
por: Huang, Mingzhu, et al.
Publicado: (2010)

Inhibition of SDF-1 receptors CXCR4 and CXCR7 attenuates acute pulmonary inflammation via the adenosine A(2B)-receptor on blood cells
por: Konrad, Franziska Magdalena, et al.
Publicado: (2017)

Stem cells migration during skeletal muscle regeneration - the role of Sdf-1/Cxcr4 and Sdf-1/Cxcr7 axis
por: Kowalski, Kamil, et al.
Publicado: (2016)

Baicalin suppresses glaucoma pathogenesis by regulating the PI3K/AKT signaling in vitro and in vivo
por: Zhao, Ningmin, et al.
Publicado: (2021)

The role of SDF-1/CXCR4 in the vasculogenesis and remodeling of cerebral arteriovenous malformation
por: Wang, Lingyan, et al.
Publicado: (2015)

SDF-1/CXCR4 axis induces human dental pulp stem cell migration through FAK/PI3K/Akt and GSK3β/β-catenin pathways
por: Li, Mingwei, et al.
Publicado: (2017)

Ginsenoside Rb1 prevents homocysteine-induced EPC dysfunction via VEGF/p38MAPK and SDF-1/CXCR4 activation
por: Lan, Tao-Hua, et al.
Publicado: (2017)

Exogenous SDF-1α Protects Human Myocardium from Hypoxia-Reoxygenation Injury via CXCR4
por: Malik, A., et al.
Publicado: (2015)

Visfatin inhibits colon cancer cell apoptosis and decreases chemosensitivity to 5-FU by promoting the SDF-1/CXCR4/Akt axis
por: Zhao, Quan, et al.
Publicado: (2022)

Fibroblast CEBPD/SDF4 axis in response to chemotherapy-induced angiogenesis through CXCR4
por: Chi, Jhih-Ying, et al.
Publicado: (2021)

Celecoxib suppresses cutaneous squamous-cell carcinoma cell migration via inhibition of SDF1-induced endocytosis of CXCR4
por: Gong, Ting, et al.
Publicado: (2018)

The Role of SDF-1-CXCR4/CXCR7 Axis in the Therapeutic Effects of Hypoxia-Preconditioned Mesenchymal Stem Cells for Renal Ischemia/Reperfusion Injury
por: Liu, Hongbao, et al.
Publicado: (2012)

Inhibition of SDF-1α/CXCR4 Signalling in Subchondral Bone Attenuates Post-Traumatic Osteoarthritis
por: Dong, Yonghui, et al.
Publicado: (2016)

Plumbagin Restrains Hepatocellular Carcinoma Angiogenesis by Stromal Cell-Derived Factor (SDF-1)/CXCR4-CXCR7 Axis
por: Zhong, Jing, et al.
Publicado: (2019)

Baicalin alleviates bleomycin-induced pulmonary fibrosis and fibroblast proliferation in rats via the PI3K/AKT signaling pathway
por: Zhao, Hong, et al.
Publicado: (2020)

Expression of SDF-1 and CXCR4 transcript variants and CXCR7 in epithelial ovarian cancer
por: JASZCZYNSKA-NOWINKA, KAROLINA, et al.
Publicado: (2014)

The Role of SDF-1/CXCR4/CXCR7 in Neuronal Regeneration after Cerebral Ischemia
por: Cheng, Xi, et al.
Publicado: (2017)

Butyric acid alleviated chronic intermittent hypoxia-induced lipid formation and inflammation through up-regulating HuR expression and inactivating AMPK pathways
por: Su, MiaoShang, et al.
Publicado: (2021)

Ginsenoside Rb1 Modulates the Migration of Bone-Derived Mesenchymal Stem Cells through the SDF-1/CXCR4 Axis and PI3K/Akt Pathway
por: Liu, Yimei, et al.
Publicado: (2022)

Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation
por: Jiang, Qin, et al.
Publicado: (2021)

Phorbol Esters and SDF-1 Induce Rapid Endocytosis and Down Modulation of the Chemokine Receptor CXCR4
por: Signoret, Natalie, et al.
Publicado: (1997)

SDF-1/CXCR7 Chemokine Signaling is Induced in the Peri-Infarct Regions in Patients with Ischemic Stroke
por: Zhang, Yu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_qfi7cc8q6a5ejptc8s4im9maot