CEACAM1 as a multi-purpose target for cancer immunotherapy

CEACAM1 is an extensively studied cell surface molecule with established functions in multiple cancer types, as well as in various compartments of the immune system. Due to its multi-faceted role as a recently appreciated immune checkpoint inhibitor and tumor marker, CEACAM1 is an attractive target...

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Autores principales: Dankner, Matthew, Gray-Owen, Scott D., Huang, Yu-Hwa, Blumberg, Richard S., Beauchemin, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543821/
https://www.ncbi.nlm.nih.gov/pubmed/28811966
http://dx.doi.org/10.1080/2162402X.2017.1328336
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author Dankner, Matthew
Gray-Owen, Scott D.
Huang, Yu-Hwa
Blumberg, Richard S.
Beauchemin, Nicole
author_facet Dankner, Matthew
Gray-Owen, Scott D.
Huang, Yu-Hwa
Blumberg, Richard S.
Beauchemin, Nicole
author_sort Dankner, Matthew
collection PubMed
description CEACAM1 is an extensively studied cell surface molecule with established functions in multiple cancer types, as well as in various compartments of the immune system. Due to its multi-faceted role as a recently appreciated immune checkpoint inhibitor and tumor marker, CEACAM1 is an attractive target for cancer immunotherapy. Herein, we highlight CEACAM1's function in various immune compartments and cancer types, including in the context of metastatic disease. This review outlines CEACAM1's role as a therapeutic target for cancer treatment in light of these properties.
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spelling pubmed-55438212017-08-15 CEACAM1 as a multi-purpose target for cancer immunotherapy Dankner, Matthew Gray-Owen, Scott D. Huang, Yu-Hwa Blumberg, Richard S. Beauchemin, Nicole Oncoimmunology Review CEACAM1 is an extensively studied cell surface molecule with established functions in multiple cancer types, as well as in various compartments of the immune system. Due to its multi-faceted role as a recently appreciated immune checkpoint inhibitor and tumor marker, CEACAM1 is an attractive target for cancer immunotherapy. Herein, we highlight CEACAM1's function in various immune compartments and cancer types, including in the context of metastatic disease. This review outlines CEACAM1's role as a therapeutic target for cancer treatment in light of these properties. Taylor & Francis 2017-05-16 /pmc/articles/PMC5543821/ /pubmed/28811966 http://dx.doi.org/10.1080/2162402X.2017.1328336 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Review
Dankner, Matthew
Gray-Owen, Scott D.
Huang, Yu-Hwa
Blumberg, Richard S.
Beauchemin, Nicole
CEACAM1 as a multi-purpose target for cancer immunotherapy
title CEACAM1 as a multi-purpose target for cancer immunotherapy
title_full CEACAM1 as a multi-purpose target for cancer immunotherapy
title_fullStr CEACAM1 as a multi-purpose target for cancer immunotherapy
title_full_unstemmed CEACAM1 as a multi-purpose target for cancer immunotherapy
title_short CEACAM1 as a multi-purpose target for cancer immunotherapy
title_sort ceacam1 as a multi-purpose target for cancer immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543821/
https://www.ncbi.nlm.nih.gov/pubmed/28811966
http://dx.doi.org/10.1080/2162402X.2017.1328336
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