PD-L1 immune suppression in cancer: Tumor cells or host cells?

Four recent publications reported the role of PD-L1 expression on host versus malignant cells within the tumor for PD-1/PD-L1 checkpoint blockade therapy. All four research groups harmoniously report: PD-L1 expressed by both host as well as tumor cells are capable of suppressing T cell functions. Th...

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Detalles Bibliográficos
Autores principales: Kleinovink, Jan Willem, van Hall, Thorbald, Ossendorp, Ferry, Fransen, Marieke F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543902/
https://www.ncbi.nlm.nih.gov/pubmed/28811961
http://dx.doi.org/10.1080/2162402X.2017.1325982
Descripción
Sumario:Four recent publications reported the role of PD-L1 expression on host versus malignant cells within the tumor for PD-1/PD-L1 checkpoint blockade therapy. All four research groups harmoniously report: PD-L1 expressed by both host as well as tumor cells are capable of suppressing T cell functions. Thus, checkpoint therapy can be effective, if malignant cells do not express PD-L1.

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