Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB

Neutrophils are increasingly associated with tuberculosis (TB) disease. Neutrophil extracellular traps (NETs), which are released by neutrophils as a host antimicrobial defense mechanism, are also associated with tissue damage. However, a link between NET levels and TB disease has not been studied....

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Detalles Bibliográficos
Autores principales: Schechter, Marcos C., Buac, Kristina, Adekambi, Toidi, Cagle, Stephanie, Celli, Justine, Ray, Susan M., Mehta, Christina C., Rada, Balázs, Rengarajan, Jyothi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544211/
https://www.ncbi.nlm.nih.gov/pubmed/28777804
http://dx.doi.org/10.1371/journal.pone.0182587
Descripción
Sumario:Neutrophils are increasingly associated with tuberculosis (TB) disease. Neutrophil extracellular traps (NETs), which are released by neutrophils as a host antimicrobial defense mechanism, are also associated with tissue damage. However, a link between NET levels and TB disease has not been studied. Here we investigate plasma NETs levels in patients with active pulmonary tuberculosis using an ELISA assay that is suitable for high-throughput processing. We show that plasma NETs levels at baseline correlated with disease severity and decreased with antibiotic therapy. Our study demonstrates the biologic plausibility of measuring NETs in plasma samples from patients with TB.

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