Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB

Neutrophils are increasingly associated with tuberculosis (TB) disease. Neutrophil extracellular traps (NETs), which are released by neutrophils as a host antimicrobial defense mechanism, are also associated with tissue damage. However, a link between NET levels and TB disease has not been studied....

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Autores principales: Schechter, Marcos C., Buac, Kristina, Adekambi, Toidi, Cagle, Stephanie, Celli, Justine, Ray, Susan M., Mehta, Christina C., Rada, Balázs, Rengarajan, Jyothi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544211/
https://www.ncbi.nlm.nih.gov/pubmed/28777804
http://dx.doi.org/10.1371/journal.pone.0182587
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author Schechter, Marcos C.
Buac, Kristina
Adekambi, Toidi
Cagle, Stephanie
Celli, Justine
Ray, Susan M.
Mehta, Christina C.
Rada, Balázs
Rengarajan, Jyothi
author_facet Schechter, Marcos C.
Buac, Kristina
Adekambi, Toidi
Cagle, Stephanie
Celli, Justine
Ray, Susan M.
Mehta, Christina C.
Rada, Balázs
Rengarajan, Jyothi
author_sort Schechter, Marcos C.
collection PubMed
description Neutrophils are increasingly associated with tuberculosis (TB) disease. Neutrophil extracellular traps (NETs), which are released by neutrophils as a host antimicrobial defense mechanism, are also associated with tissue damage. However, a link between NET levels and TB disease has not been studied. Here we investigate plasma NETs levels in patients with active pulmonary tuberculosis using an ELISA assay that is suitable for high-throughput processing. We show that plasma NETs levels at baseline correlated with disease severity and decreased with antibiotic therapy. Our study demonstrates the biologic plausibility of measuring NETs in plasma samples from patients with TB.
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spelling pubmed-55442112017-08-12 Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB Schechter, Marcos C. Buac, Kristina Adekambi, Toidi Cagle, Stephanie Celli, Justine Ray, Susan M. Mehta, Christina C. Rada, Balázs Rengarajan, Jyothi PLoS One Research Article Neutrophils are increasingly associated with tuberculosis (TB) disease. Neutrophil extracellular traps (NETs), which are released by neutrophils as a host antimicrobial defense mechanism, are also associated with tissue damage. However, a link between NET levels and TB disease has not been studied. Here we investigate plasma NETs levels in patients with active pulmonary tuberculosis using an ELISA assay that is suitable for high-throughput processing. We show that plasma NETs levels at baseline correlated with disease severity and decreased with antibiotic therapy. Our study demonstrates the biologic plausibility of measuring NETs in plasma samples from patients with TB. Public Library of Science 2017-08-04 /pmc/articles/PMC5544211/ /pubmed/28777804 http://dx.doi.org/10.1371/journal.pone.0182587 Text en © 2017 Schechter et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Schechter, Marcos C.
Buac, Kristina
Adekambi, Toidi
Cagle, Stephanie
Celli, Justine
Ray, Susan M.
Mehta, Christina C.
Rada, Balázs
Rengarajan, Jyothi
Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB
title Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB
title_full Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB
title_fullStr Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB
title_full_unstemmed Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB
title_short Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB
title_sort neutrophil extracellular trap (net) levels in human plasma are associated with active tb
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544211/
https://www.ncbi.nlm.nih.gov/pubmed/28777804
http://dx.doi.org/10.1371/journal.pone.0182587
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