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Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function

Coordinated cardiomyocyte growth, differentiation, and morphogenesis are essential for heart formation. We demonstrate that the bHLH transcription factors Hand1 and Hand2 play critical regulatory roles for left ventricle (LV) cardiomyocyte proliferation and morphogenesis. Using an LV-specific Cre al...

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Detalles Bibliográficos
Autores principales:	Vincentz, Joshua W., Toolan, Kevin P., Zhang, Wenjun, Firulli, Anthony B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544250/ https://www.ncbi.nlm.nih.gov/pubmed/28732025 http://dx.doi.org/10.1371/journal.pgen.1006922

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