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CRISPR-mediated genetic interaction profiling identifies RNA binding proteins controlling metazoan fitness

Genetic interaction screens have aided our understanding of complex genetic traits, diseases, and biological pathways. However, approaches for synthetic genetic analysis with null-alleles in metazoans have not been feasible. Here, we present a CRISPR/Cas9-based Synthetic Genetic Interaction (CRISPR-...

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Detalles Bibliográficos
Autores principales:	Norris, Adam D, Gracida, Xicotencatl, Calarco, John A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Genes and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544425/ https://www.ncbi.nlm.nih.gov/pubmed/28718764 http://dx.doi.org/10.7554/eLife.28129

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