Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein

The amyloid precursor protein (APP) harbors physiological roles at synapses and is central to Alzheimer’s disease (AD) pathogenesis. Evidence suggests that APP intracellular domain (AICD) could regulate synapse function, but the underlying molecular mechanisms remain unknown. We addressed AICD actio...

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Detalles Bibliográficos
Autores principales: Pousinha, Paula A, Mouska, Xavier, Raymond, Elisabeth F, Gwizdek, Carole, Dhib, Gihen, Poupon, Gwenola, Zaragosi, Laure-Emmanuelle, Giudici, Camilla, Bethus, Ingrid, Pacary, Emilie, Willem, Michael, Marie, Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544428/
https://www.ncbi.nlm.nih.gov/pubmed/28682239
http://dx.doi.org/10.7554/eLife.25659

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