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A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi

Component-based Chinese medicine (CCM) is derived from traditional Chinese medicine but produced with modern pharmaceutical standard and clearer clinical indications. However, it still faces challenges of defining individual component contribution in the complex formula. Using QiShenYiQi (QSYQ) as a...

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Autores principales: Yu, Jiahui, Zhang, Wen, Zhang, Yiqian, Wang, Yadong, Zhang, Boli, Fan, Guanwei, Zhu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544742/
https://www.ncbi.nlm.nih.gov/pubmed/28779167
http://dx.doi.org/10.1038/s41598-017-07659-x
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author Yu, Jiahui
Zhang, Wen
Zhang, Yiqian
Wang, Yadong
Zhang, Boli
Fan, Guanwei
Zhu, Yan
author_facet Yu, Jiahui
Zhang, Wen
Zhang, Yiqian
Wang, Yadong
Zhang, Boli
Fan, Guanwei
Zhu, Yan
author_sort Yu, Jiahui
collection PubMed
description Component-based Chinese medicine (CCM) is derived from traditional Chinese medicine but produced with modern pharmaceutical standard and clearer clinical indications. However, it still faces challenges of defining individual component contribution in the complex formula. Using QiShenYiQi (QSYQ) as a model CCM, we investigated the role of Dalbergia odorifera (DO), an herbal component, in preventing myocardial damage. We showed that in vitro, QSYQ exerted considerable protective activities on cardiomyocytes from H(2)O(2)-induced mitochondrial dysfunction with or without DO. However, in isolated rat hearts, myocardial protection by QSYQ was significantly weakened without DO. In everted gut sac model, DO significantly enhanced absorption of the major QSYQ ingredients in different regions of rat intestine. Finally, in in vivo mouse model of doxorubicin (DOX)-induced myocardial damage, only QSYQ, but not QiShenYiQi without DO (QSYQ-DO), exerted a full protection. Taken together, our results showed that instead of directly contributing to the myocardial protection, Dalbergia odorifera facilitates the major active ingredients absorption and increases their efficacy, eventually enhancing the in vivo potency of QSYQ. These findings may shed new lights on our understanding of the prescription compatibility theory, as well as the impacts of “courier herbs” in component-based Chinese medicine.
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spelling pubmed-55447422017-08-09 A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi Yu, Jiahui Zhang, Wen Zhang, Yiqian Wang, Yadong Zhang, Boli Fan, Guanwei Zhu, Yan Sci Rep Article Component-based Chinese medicine (CCM) is derived from traditional Chinese medicine but produced with modern pharmaceutical standard and clearer clinical indications. However, it still faces challenges of defining individual component contribution in the complex formula. Using QiShenYiQi (QSYQ) as a model CCM, we investigated the role of Dalbergia odorifera (DO), an herbal component, in preventing myocardial damage. We showed that in vitro, QSYQ exerted considerable protective activities on cardiomyocytes from H(2)O(2)-induced mitochondrial dysfunction with or without DO. However, in isolated rat hearts, myocardial protection by QSYQ was significantly weakened without DO. In everted gut sac model, DO significantly enhanced absorption of the major QSYQ ingredients in different regions of rat intestine. Finally, in in vivo mouse model of doxorubicin (DOX)-induced myocardial damage, only QSYQ, but not QiShenYiQi without DO (QSYQ-DO), exerted a full protection. Taken together, our results showed that instead of directly contributing to the myocardial protection, Dalbergia odorifera facilitates the major active ingredients absorption and increases their efficacy, eventually enhancing the in vivo potency of QSYQ. These findings may shed new lights on our understanding of the prescription compatibility theory, as well as the impacts of “courier herbs” in component-based Chinese medicine. Nature Publishing Group UK 2017-08-04 /pmc/articles/PMC5544742/ /pubmed/28779167 http://dx.doi.org/10.1038/s41598-017-07659-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yu, Jiahui
Zhang, Wen
Zhang, Yiqian
Wang, Yadong
Zhang, Boli
Fan, Guanwei
Zhu, Yan
A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi
title A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi
title_full A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi
title_fullStr A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi
title_full_unstemmed A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi
title_short A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi
title_sort critical courier role of volatile oils from dalbergia odorifera for cardiac protection in vivo by qishenyiqi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544742/
https://www.ncbi.nlm.nih.gov/pubmed/28779167
http://dx.doi.org/10.1038/s41598-017-07659-x
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