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Targeting primary acute myeloid leukemia with a new CXCR4 antagonist IgG1 antibody (PF-06747143)

The chemokine receptor CXCR4 mediates cell anchorage in the bone marrow (BM) microenvironment and is overexpressed in 25–30% of patients with acute myeloid leukemia (AML). Here we have shown that a new CXCR4 receptor antagonist IgG1 antibody (PF-06747143) binds strongly to AML cell lines and to AML...

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Detalles Bibliográficos
Autores principales:	Zhang, Yanyan, Saavedra, Erika, Tang, Ruoping, Gu, Yin, Lappin, Patrick, Trajkovic, Dusko, Liu, Shu-Hui, Smeal, Tod, Fantin, Valeria, De Botton, Stephane, Legrand, Ollivier, Delhommeau, Francois, Pernasetti, Flavia, Louache, Fawzia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544749/ https://www.ncbi.nlm.nih.gov/pubmed/28779088 http://dx.doi.org/10.1038/s41598-017-07848-8

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