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The Phenotype of Patients with a Recent Fracture: A Literature Survey of the Fracture Liaison Service

The aetiology of fractures in patients aged 50 years and older is multifactorial, and includes bone- and fall-related risks. The Fracture Liaison Service (FLS) is recommended to identify patients with a recent fracture and to evaluate their subsequent fracture risk, in order to take measures to decr...

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Autores principales: Vranken, Lisanne, Wyers, Caroline E., van den Bergh, Joop P. W., Geusens, Piet P. M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544781/
https://www.ncbi.nlm.nih.gov/pubmed/28536889
http://dx.doi.org/10.1007/s00223-017-0284-1
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author Vranken, Lisanne
Wyers, Caroline E.
van den Bergh, Joop P. W.
Geusens, Piet P. M. M.
author_facet Vranken, Lisanne
Wyers, Caroline E.
van den Bergh, Joop P. W.
Geusens, Piet P. M. M.
author_sort Vranken, Lisanne
collection PubMed
description The aetiology of fractures in patients aged 50 years and older is multifactorial, and includes bone- and fall-related risks. The Fracture Liaison Service (FLS) is recommended to identify patients with a recent fracture and to evaluate their subsequent fracture risk, in order to take measures to decrease the risk of subsequent fractures in patients with a high risk phenotype. A literature survey was conducted to describe components of the bone- and fall-related phenotype of patients attending the FLS. Components of the patient phenotype at the FLS have been reported in 33 studies. Patient selection varied widely in terms of patient identification, selection, and FLS attendance. Consequently, there was a high variability in FLS patient characteristics, such as mean age (64–80 years), proportion of men (13–30%), and fracture locations (2–51% hip, <1–41% vertebral, and 49–95% non-hip, non-vertebral fractures). The studies also varied in the risk evaluation performed. When reported, there was a highly variability in the percentage of patients with osteoporosis (12–54%), prevalent vertebral fractures (20–57%), newly diagnosed contributors to secondary osteoporosis and metabolic bone disorders (3–70%), and fall-related risk factors (60–84%). In FLS literature, we found a high variability in patient selection and risk evaluation, resulting in a highly variable phenotype. In order to specify the bone- and fall related phenotypes at the FLS, systematic studies on the presence and combinations of these risks are needed.
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spelling pubmed-55447812017-08-18 The Phenotype of Patients with a Recent Fracture: A Literature Survey of the Fracture Liaison Service Vranken, Lisanne Wyers, Caroline E. van den Bergh, Joop P. W. Geusens, Piet P. M. M. Calcif Tissue Int Review The aetiology of fractures in patients aged 50 years and older is multifactorial, and includes bone- and fall-related risks. The Fracture Liaison Service (FLS) is recommended to identify patients with a recent fracture and to evaluate their subsequent fracture risk, in order to take measures to decrease the risk of subsequent fractures in patients with a high risk phenotype. A literature survey was conducted to describe components of the bone- and fall-related phenotype of patients attending the FLS. Components of the patient phenotype at the FLS have been reported in 33 studies. Patient selection varied widely in terms of patient identification, selection, and FLS attendance. Consequently, there was a high variability in FLS patient characteristics, such as mean age (64–80 years), proportion of men (13–30%), and fracture locations (2–51% hip, <1–41% vertebral, and 49–95% non-hip, non-vertebral fractures). The studies also varied in the risk evaluation performed. When reported, there was a highly variability in the percentage of patients with osteoporosis (12–54%), prevalent vertebral fractures (20–57%), newly diagnosed contributors to secondary osteoporosis and metabolic bone disorders (3–70%), and fall-related risk factors (60–84%). In FLS literature, we found a high variability in patient selection and risk evaluation, resulting in a highly variable phenotype. In order to specify the bone- and fall related phenotypes at the FLS, systematic studies on the presence and combinations of these risks are needed. Springer US 2017-05-24 2017 /pmc/articles/PMC5544781/ /pubmed/28536889 http://dx.doi.org/10.1007/s00223-017-0284-1 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Vranken, Lisanne
Wyers, Caroline E.
van den Bergh, Joop P. W.
Geusens, Piet P. M. M.
The Phenotype of Patients with a Recent Fracture: A Literature Survey of the Fracture Liaison Service
title The Phenotype of Patients with a Recent Fracture: A Literature Survey of the Fracture Liaison Service
title_full The Phenotype of Patients with a Recent Fracture: A Literature Survey of the Fracture Liaison Service
title_fullStr The Phenotype of Patients with a Recent Fracture: A Literature Survey of the Fracture Liaison Service
title_full_unstemmed The Phenotype of Patients with a Recent Fracture: A Literature Survey of the Fracture Liaison Service
title_short The Phenotype of Patients with a Recent Fracture: A Literature Survey of the Fracture Liaison Service
title_sort phenotype of patients with a recent fracture: a literature survey of the fracture liaison service
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544781/
https://www.ncbi.nlm.nih.gov/pubmed/28536889
http://dx.doi.org/10.1007/s00223-017-0284-1
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