Disruption of the Aldehyde Dehydrogenase 2 Gene Results in No Increase in Trabecular Bone Mass Due to Skeletal Loading in Association with Impaired Cell Cycle Regulation Through p21 Expression in the Bone Marrow Cells of Mice

Approximately 45% of people of East Asian descent have the inactive aldehyde dehydrogenase 2 (ALDH2) phenotype. The enzyme defect of ALDH2 has been found to adversely influence the risk of osteoporosis. The aim of this study was to clarify the effect of skeletal loading on trabecular bone structure...

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Detalles Bibliográficos
Autores principales: Okuma, Kayoko Furukawa, Menuki, Kunitaka, Tsukamoto, Manabu, Tajima, Takafumi, Fukuda, Hokuto, Okada, Yasuaki, Mori, Toshiharu, Tsuchiya, Takuto, Kawamoto, Toshihiro, Yoshida, Yasuhiro, Uchida, Soshi, Sakai, Akinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544803/
https://www.ncbi.nlm.nih.gov/pubmed/28474171
http://dx.doi.org/10.1007/s00223-017-0285-0

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