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Fiber-reinforced scaffolds in soft tissue engineering
Soft tissue engineering has been developed as a new strategy for repairing damaged or diseased soft tissues and organs to overcome the limitations of current therapies. Since most of soft tissues in the human body are usually supported by collagen fibers to form a three-dimensional microstructure, f...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544910/ https://www.ncbi.nlm.nih.gov/pubmed/28798872 http://dx.doi.org/10.1093/rb/rbx021 |
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author | Pei, Baoqing Wang, Wei Fan, Yubo Wang, Xiumei Watari, Fumio Li, Xiaoming |
author_facet | Pei, Baoqing Wang, Wei Fan, Yubo Wang, Xiumei Watari, Fumio Li, Xiaoming |
author_sort | Pei, Baoqing |
collection | PubMed |
description | Soft tissue engineering has been developed as a new strategy for repairing damaged or diseased soft tissues and organs to overcome the limitations of current therapies. Since most of soft tissues in the human body are usually supported by collagen fibers to form a three-dimensional microstructure, fiber-reinforced scaffolds have the advantage to mimic the structure, mechanical and biological environment of natural soft tissues, which benefits for their regeneration and remodeling. This article reviews and discusses the latest research advances on design and manufacture of novel fiber-reinforced scaffolds for soft tissue repair and how fiber addition affects their structural characteristics, mechanical strength and biological activities in vitro and in vivo. In general, the concept of fiber-reinforced scaffolds with adjustable microstructures, mechanical properties and degradation rates can provide an effective platform and promising method for developing satisfactory biomechanically functional implantations for soft tissue engineering or regenerative medicine. |
format | Online Article Text |
id | pubmed-5544910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-55449102017-08-10 Fiber-reinforced scaffolds in soft tissue engineering Pei, Baoqing Wang, Wei Fan, Yubo Wang, Xiumei Watari, Fumio Li, Xiaoming Regen Biomater Review Soft tissue engineering has been developed as a new strategy for repairing damaged or diseased soft tissues and organs to overcome the limitations of current therapies. Since most of soft tissues in the human body are usually supported by collagen fibers to form a three-dimensional microstructure, fiber-reinforced scaffolds have the advantage to mimic the structure, mechanical and biological environment of natural soft tissues, which benefits for their regeneration and remodeling. This article reviews and discusses the latest research advances on design and manufacture of novel fiber-reinforced scaffolds for soft tissue repair and how fiber addition affects their structural characteristics, mechanical strength and biological activities in vitro and in vivo. In general, the concept of fiber-reinforced scaffolds with adjustable microstructures, mechanical properties and degradation rates can provide an effective platform and promising method for developing satisfactory biomechanically functional implantations for soft tissue engineering or regenerative medicine. Oxford University Press 2017-08 2017-08-04 /pmc/articles/PMC5544910/ /pubmed/28798872 http://dx.doi.org/10.1093/rb/rbx021 Text en © The Author(s) 2017. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Pei, Baoqing Wang, Wei Fan, Yubo Wang, Xiumei Watari, Fumio Li, Xiaoming Fiber-reinforced scaffolds in soft tissue engineering |
title | Fiber-reinforced scaffolds in soft tissue engineering |
title_full | Fiber-reinforced scaffolds in soft tissue engineering |
title_fullStr | Fiber-reinforced scaffolds in soft tissue engineering |
title_full_unstemmed | Fiber-reinforced scaffolds in soft tissue engineering |
title_short | Fiber-reinforced scaffolds in soft tissue engineering |
title_sort | fiber-reinforced scaffolds in soft tissue engineering |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544910/ https://www.ncbi.nlm.nih.gov/pubmed/28798872 http://dx.doi.org/10.1093/rb/rbx021 |
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