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Inhibition of basal-like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade

BACKGROUND: New molecular targets are needed for women with triple-negative breast cancer (TNBC). This pre-clinical study investigated the combination of the EGFR inhibitor gefitinib with the sphingosine kinase (SphK) inhibitor FTY720 (Fingolimod), aiming to block tumorigenic signaling downstream of...

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Detalles Bibliográficos
Autores principales:	Martin, Janet L., Julovi, Sohel M., Lin, Mike Z., de Silva, Hasanthi C., Boyle, Frances M., Baxter, Robert C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545026/ https://www.ncbi.nlm.nih.gov/pubmed/28778177 http://dx.doi.org/10.1186/s13058-017-0882-x

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