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The clonal evolution of two distinct T315I-positive BCR-ABL1 subclones in a Philadelphia-positive acute lymphoblastic leukemia failing multiple lines of therapy: a case report

BACKGROUND: The treatment of Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL) patients who harbor the T315I BCR-ABL1 mutation or who have two or more mutations in the same BCR-ABL1 molecule is particularly challenging since first and second-generation Tyrosine Kinase Inhibitor...

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Detalles Bibliográficos
Autores principales:	De Benedittis, Caterina, Papayannidis, Cristina, Venturi, Claudia, Abbenante, Maria Chiara, Paolini, Stefania, Parisi, Sarah, Sartor, Chiara, Cavo, Michele, Martinelli, Giovanni, Soverini, Simona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545087/ https://www.ncbi.nlm.nih.gov/pubmed/28779753 http://dx.doi.org/10.1186/s12885-017-3511-2

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