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Uncoupling conformational states from activity in an allosteric enzyme

ATP-phosphoribosyltransferase (ATP-PRT) is a hexameric enzyme in conformational equilibrium between an open and seemingly active state and a closed and presumably inhibited form. The structure-function relationship of allosteric regulation in this system is still not fully understood. Here, we devel...

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Detalles Bibliográficos
Autores principales:	Pisco, João P., de Chiara, Cesira, Pacholarz, Kamila J., Garza-Garcia, Acely, Ogrodowicz, Roksana W., Walker, Philip A., Barran, Perdita E., Smerdon, Stephen J., de Carvalho, Luiz Pedro S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545217/ https://www.ncbi.nlm.nih.gov/pubmed/28781362 http://dx.doi.org/10.1038/s41467-017-00224-0

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