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Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice
Some chemicals are known to be lung carcinogens in rodents. While many studies using two-stage models have administered medium or high doses to mice, few have tested lower doses. The dose dependence of urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P), t...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Japanese Society of Toxicologic Pathology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545673/ https://www.ncbi.nlm.nih.gov/pubmed/28798528 http://dx.doi.org/10.1293/tox.2017-0005 |
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author | Onami, Saeko Okubo, Chigusa Iwanaga, Asuka Suzuki, Hiroaki Iida, Hajime Motohashi, Yurie Tomonari, Yuki Otake, Seiji Tsuji, Hiroyuki Yoshimura, Hiroyuki |
author_facet | Onami, Saeko Okubo, Chigusa Iwanaga, Asuka Suzuki, Hiroaki Iida, Hajime Motohashi, Yurie Tomonari, Yuki Otake, Seiji Tsuji, Hiroyuki Yoshimura, Hiroyuki |
author_sort | Onami, Saeko |
collection | PubMed |
description | Some chemicals are known to be lung carcinogens in rodents. While many studies using two-stage models have administered medium or high doses to mice, few have tested lower doses. The dose dependence of urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P), three well-known lung carcinogens at high doses, has not been sufficiently reported in lower dose ranges. Our study evaluated the tumorigenicity of urethane, NNK, and B[a]P at 26 weeks after a single intraperitoneal administration of each compound within medium to low dose in male and/or female A/JJmsSlc (A/J) mice. Dose-dependent tumorigenesis was demonstrated histopathologically for the three compounds. These results suggested that the tumorigenicity of these chemicals is dose dependent in A/J mice, even at lower doses than previously reported. |
format | Online Article Text |
id | pubmed-5545673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Japanese Society of Toxicologic Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-55456732017-08-10 Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice Onami, Saeko Okubo, Chigusa Iwanaga, Asuka Suzuki, Hiroaki Iida, Hajime Motohashi, Yurie Tomonari, Yuki Otake, Seiji Tsuji, Hiroyuki Yoshimura, Hiroyuki J Toxicol Pathol Original Article Some chemicals are known to be lung carcinogens in rodents. While many studies using two-stage models have administered medium or high doses to mice, few have tested lower doses. The dose dependence of urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P), three well-known lung carcinogens at high doses, has not been sufficiently reported in lower dose ranges. Our study evaluated the tumorigenicity of urethane, NNK, and B[a]P at 26 weeks after a single intraperitoneal administration of each compound within medium to low dose in male and/or female A/JJmsSlc (A/J) mice. Dose-dependent tumorigenesis was demonstrated histopathologically for the three compounds. These results suggested that the tumorigenicity of these chemicals is dose dependent in A/J mice, even at lower doses than previously reported. Japanese Society of Toxicologic Pathology 2017-03-31 2017-07 /pmc/articles/PMC5545673/ /pubmed/28798528 http://dx.doi.org/10.1293/tox.2017-0005 Text en ©2017 The Japanese Society of Toxicologic Pathology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Onami, Saeko Okubo, Chigusa Iwanaga, Asuka Suzuki, Hiroaki Iida, Hajime Motohashi, Yurie Tomonari, Yuki Otake, Seiji Tsuji, Hiroyuki Yoshimura, Hiroyuki Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice |
title | Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice |
title_full | Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice |
title_fullStr | Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice |
title_full_unstemmed | Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice |
title_short | Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice |
title_sort | dosimetry for lung tumorigenesis induced by urethane, 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone (nnk), and benzo[a]pyrene (b[a]p) in a/jjmsslc mice |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545673/ https://www.ncbi.nlm.nih.gov/pubmed/28798528 http://dx.doi.org/10.1293/tox.2017-0005 |
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