The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases

Antigenic peptides presented by the major histocompatibility complex class I (MHC-I) molecules for recognition by cytotoxic T-lymphocytes are processed by members of the oxytocinase sub-family of M1 aminopeptidases ERAP1, ERAP2, and IRAP. These three homologous zinc metallopeptidases trim N-terminal...

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Detalles Bibliográficos
Autores principales: Papakyriakou, Athanasios, Stratikos, Efstratios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545687/
https://www.ncbi.nlm.nih.gov/pubmed/28824657
http://dx.doi.org/10.3389/fimmu.2017.00946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545687/
https://www.ncbi.nlm.nih.gov/pubmed/28824657
http://dx.doi.org/10.3389/fimmu.2017.00946

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