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The effect of high-fat diet on rat’s mood, feeding behavior and response to stress

An association between obesity and depression has been indicated in studies addressing common physical (metabolic) and psychological (anxiety, low self-esteem) outcomes. Of consideration in both obesity and depression are chronic mild stressors to which individuals are exposed to on a daily basis. H...

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Autores principales: Aslani, S, Vieira, N, Marques, F, Costa, P S, Sousa, N, Palha, J A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545690/
https://www.ncbi.nlm.nih.gov/pubmed/26795748
http://dx.doi.org/10.1038/tp.2015.178
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author Aslani, S
Vieira, N
Marques, F
Costa, P S
Sousa, N
Palha, J A
author_facet Aslani, S
Vieira, N
Marques, F
Costa, P S
Sousa, N
Palha, J A
author_sort Aslani, S
collection PubMed
description An association between obesity and depression has been indicated in studies addressing common physical (metabolic) and psychological (anxiety, low self-esteem) outcomes. Of consideration in both obesity and depression are chronic mild stressors to which individuals are exposed to on a daily basis. However, the response to stress is remarkably variable depending on numerous factors, such as the physical health and the mental state at the time of exposure. Here a chronic mild stress (CMS) protocol was used to assess the effect of high-fat diet (HFD)-induced obesity on response to stress in a rat model. In addition to the development of metabolic complications, such as glucose intolerance, diet-induced obesity caused behavioral alterations. Specifically, animals fed on HFD displayed depressive- and anxious-like behaviors that were only present in the normal diet (ND) group upon exposure to CMS. Of notice, these mood impairments were not further aggravated when the HFD animals were exposed to CMS, which suggest a ceiling effect. Moreover, although there was a sudden drop of food consumption in the first 3 weeks of the CMS protocol in both ND and HFD groups, only the CMS-HFD displayed an overall noticeable decrease in total food intake during the 6 weeks of the CMS protocol. Altogether, the study suggests that HFD impacts on the response to CMS, which should be considered when addressing the consequences of obesity in behavior.
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spelling pubmed-55456902017-08-09 The effect of high-fat diet on rat’s mood, feeding behavior and response to stress Aslani, S Vieira, N Marques, F Costa, P S Sousa, N Palha, J A Transl Psychiatry Original Article An association between obesity and depression has been indicated in studies addressing common physical (metabolic) and psychological (anxiety, low self-esteem) outcomes. Of consideration in both obesity and depression are chronic mild stressors to which individuals are exposed to on a daily basis. However, the response to stress is remarkably variable depending on numerous factors, such as the physical health and the mental state at the time of exposure. Here a chronic mild stress (CMS) protocol was used to assess the effect of high-fat diet (HFD)-induced obesity on response to stress in a rat model. In addition to the development of metabolic complications, such as glucose intolerance, diet-induced obesity caused behavioral alterations. Specifically, animals fed on HFD displayed depressive- and anxious-like behaviors that were only present in the normal diet (ND) group upon exposure to CMS. Of notice, these mood impairments were not further aggravated when the HFD animals were exposed to CMS, which suggest a ceiling effect. Moreover, although there was a sudden drop of food consumption in the first 3 weeks of the CMS protocol in both ND and HFD groups, only the CMS-HFD displayed an overall noticeable decrease in total food intake during the 6 weeks of the CMS protocol. Altogether, the study suggests that HFD impacts on the response to CMS, which should be considered when addressing the consequences of obesity in behavior. Nature Publishing Group 2015-11 2015-11-24 /pmc/articles/PMC5545690/ /pubmed/26795748 http://dx.doi.org/10.1038/tp.2015.178 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Aslani, S
Vieira, N
Marques, F
Costa, P S
Sousa, N
Palha, J A
The effect of high-fat diet on rat’s mood, feeding behavior and response to stress
title The effect of high-fat diet on rat’s mood, feeding behavior and response to stress
title_full The effect of high-fat diet on rat’s mood, feeding behavior and response to stress
title_fullStr The effect of high-fat diet on rat’s mood, feeding behavior and response to stress
title_full_unstemmed The effect of high-fat diet on rat’s mood, feeding behavior and response to stress
title_short The effect of high-fat diet on rat’s mood, feeding behavior and response to stress
title_sort effect of high-fat diet on rat’s mood, feeding behavior and response to stress
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545690/
https://www.ncbi.nlm.nih.gov/pubmed/26795748
http://dx.doi.org/10.1038/tp.2015.178
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