Cargando…

A methylome-wide mQTL analysis reveals associations of methylation sites with GAD1 and HDAC3 SNPs and a general psychiatric risk score

Genome-wide association studies have identified a number of single-nucleotide polymorphisms (SNPs) that are associated with psychiatric diseases. Increasing body of evidence suggests a complex connection of SNPs and the transcriptional and epigenetic regulation of gene expression, which is poorly un...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ciuculete, D M, Boström, A E, Voisin, S, Philipps, H, Titova, O E, Bandstein, M, Nikontovic, L, Williams, M J, Mwinyi, J, Schiöth, H B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545735/ https://www.ncbi.nlm.nih.gov/pubmed/28094813 http://dx.doi.org/10.1038/tp.2016.275

Ejemplares similares

meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes
por: Ciuculete, Diana M., et al.
Publicado: (2020)

Integrate GWAS, eQTL, and mQTL Data to Identify Alzheimer’s Disease-Related Genes
por: Zhao, Tianyi, et al.
Publicado: (2019)

Mendelian Randomization Integrating GWAS, eQTL, and mQTL Data Identified Genes Pleiotropically Associated With Atrial Fibrillation
por: Liu, Yaozhong, et al.
Publicado: (2021)

Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis
por: Kraus, William E., et al.
Publicado: (2015)

Genetic analysis of phenylpropanoids and antioxidant capacity in strawberry fruit reveals mQTL hotspots and candidate genes
por: Pott, Delphine M., et al.
Publicado: (2020)

mQTL-seq delineates functionally relevant candidate gene harbouring a major QTL regulating pod number in chickpea
por: Das, Shouvik, et al.
Publicado: (2016)

Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression
por: Ciuculete, Diana M., et al.
Publicado: (2019)

Hypermethylation-associated downregulation of microRNA-4456 in hypersexual disorder with putative influence on oxytocin signalling: A DNA methylation analysis of miRNA genes
por: Boström, Adrian E., et al.
Publicado: (2019)

Genetic analysis of metabolites in apple fruits indicates an mQTL hotspot for phenolic compounds on linkage group 16
por: Khan, Sabaz Ali, et al.
Publicado: (2012)

A Genetic Risk Score Is Associated with Weight Loss Following Roux-en Y Gastric Bypass Surgery
por: Bandstein, Marcus, et al.
Publicado: (2016)

Epigenetic Changes in the CRH Gene are Related to Severity of Suicide Attempt and a General Psychiatric Risk Score in Adolescents
por: Jokinen, Jussi, et al.
Publicado: (2017)

Association and cis-mQTL analysis of variants in serotonergic genes associated with nicotine dependence in Chinese Han smokers
por: Han, Haijun, et al.
Publicado: (2018)

A genetic variant in proximity to the gene LYPLAL1 is associated with lower hunger feelings and increased weight loss following Roux-en-Y gastric bypass surgery
por: Bandstein, Marcus, et al.
Publicado: (2016)

The mQTL hotspot on linkage group 16 for phenolic compounds in apple fruits is probably the result of a leucoanthocyanidin reductase gene at that locus
por: Khan, Sabaz Ali, et al.
Publicado: (2012)

Genetic dissection of metabolite variation in Arabidopsis seeds: evidence for mQTL hotspots and a master regulatory locus of seed metabolism
por: Knoch, Dominic, et al.
Publicado: (2017)

Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors
por: Moore, Amy, et al.
Publicado: (2022)

Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function
por: Mortlock, Sally, et al.
Publicado: (2023)

Challenges in Analyzing Functional Epigenetic Data in Perspective of Adolescent Psychiatric Health
por: Manu, Diana M., et al.
Publicado: (2022)

Longitudinal genome-wide methylation study of Roux-en-Y gastric bypass patients reveals novel CpG sites associated with essential hypertension
por: Boström, Adrian E., et al.
Publicado: (2016)

Non-steroidal anti-inflammatory drug target gene associations with major depressive disorders: a Mendelian randomisation study integrating GWAS, eQTL and mQTL Data
por: He, Qian, et al.
Publicado: (2023)

A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits
por: Volkov, Petr, et al.
Publicado: (2016)

Genetic analysis of stilbenoid profiles in grapevine stems reveals a major mQTL hotspot on chromosome 18 associated with disease-resistance motifs
por: Teh, Soon L., et al.
Publicado: (2019)

Meta-QTL and ortho-MQTL analyses identified genomic regions controlling rice yield, yield-related traits and root architecture under water deficit conditions
por: Khahani, Bahman, et al.
Publicado: (2021)

Exploring the genic resources underlying metabolites through mGWAS and mQTL in wheat: From large-scale gene identification and pathway elucidation to crop improvement
por: Chen, Jie, et al.
Publicado: (2021)

DNA methylation regulator-mediated modification patterns and risk of intracranial aneurysm: a multi-omics and epigenome-wide association study integrating machine learning, Mendelian randomization, eQTL and mQTL data
por: Maimaiti, Aierpati, et al.
Publicado: (2023)

Epigenomics of Total Acute Sleep Deprivation in Relation to Genome-Wide DNA Methylation Profiles and RNA Expression
por: Nilsson, Emil K., et al.
Publicado: (2016)

Colon-specific eQTL analysis to inform on functional SNPs
por: Moreno, Victor, et al.
Publicado: (2018)

Associations between chronotype, MTNR1B genotype and risk of type 2 diabetes in UK Biobank
por: Tan, X., et al.
Publicado: (2019)

Association and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population
por: Liu, Qiang, et al.
Publicado: (2018)

Are Psychiatric Diagnoses an Obstacle for Research and Practice? Reliability, Validity and the Problem of Psychiatric Diagnoses. The Case of GAD
por: Faravelli, Carlo, et al.
Publicado: (2012)

Good MRI images: to Gad or not to Gad?
por: Steen, Henning, et al.
Publicado: (2007)

HPA axis dysregulation is associated with differential methylation of CpG-sites in related genes
por: Chatzittofis, Andreas, et al.
Publicado: (2021)

A pharmacogenetic risk score for the evaluation of major depression severity under treatment with antidepressants
por: Kanders, Sofia H., et al.
Publicado: (2019)

Proposal for the award of a contract for the supply of the MQT, MQS and MQTL superconducting quadrupole corrector magnets for the LHC
Publicado: (2000)

An Analysis of the Cross-Reactivity of Autoantibodies to GAD65 and GAD67 in Diabetes
por: Jayakrishnan, Bindu, et al.
Publicado: (2011)

Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD(67) expression in an in vitro hippocampal GABA neuron model
por: Subburaju, S, et al.
Publicado: (2016)

A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease
por: Schiöth, Helgi B., et al.
Publicado: (2016)

Toll-like receptor 4 methylation grade is linked to depressive symptom severity
por: Rasmusson, Annica J., et al.
Publicado: (2021)

Identification of Candidate mRNA Isoforms for Prostate Cancer-Risk SNPs Utilizing Iso-eQTL and sQTL Methods
por: Moradi, Afshin, et al.
Publicado: (2022)

Expression of GAD67 and Novel GAD67 Splice Variants During Human Fetal Pancreas Development: GAD67 Expression in the Fetal Pancreas
por: Korpershoek, Esther, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_b0oagd24fbiisp3ohq7e6sn31n