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Epidemiological and clinical peculiarities of polyglandular syndrome type 3 in pediatric age

BACKGROUND: Although the autoimmune polyglandular syndrome type 3 (APS-3) is the commonest APS that may be encountered in pediatric age, last year literature includes only few studies aiming to specifically ascertain the clinical spectrum of APS-3 in childhood and adolescence. Aims of these study we...

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Autores principales: Valenzise, Mariella, Aversa, Tommaso, Saccomanno, Angiola, De Luca, Filippo, Salzano, Giuseppina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545841/
https://www.ncbi.nlm.nih.gov/pubmed/28784159
http://dx.doi.org/10.1186/s13052-017-0386-4
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author Valenzise, Mariella
Aversa, Tommaso
Saccomanno, Angiola
De Luca, Filippo
Salzano, Giuseppina
author_facet Valenzise, Mariella
Aversa, Tommaso
Saccomanno, Angiola
De Luca, Filippo
Salzano, Giuseppina
author_sort Valenzise, Mariella
collection PubMed
description BACKGROUND: Although the autoimmune polyglandular syndrome type 3 (APS-3) is the commonest APS that may be encountered in pediatric age, last year literature includes only few studies aiming to specifically ascertain the clinical spectrum of APS-3 in childhood and adolescence. Aims of these study were: a) to ascertain how many young patients with apparently isolated Hashimoto’s thyroiditis (HT) are at risk of manifesting other autoimmune disorders (ADs) compatible with APS-3; b) to individuate the ADs which most frequently segregate with HT in the context of an APS-3. METHODS: A selected population of 211 young patients with HT and no risk factors for other APSs was investigated, in order to evaluate the prevalence of other ADs apart from HT and to individuate the ADs which most frequently cluster with HT in the context of APS-3. RESULTS: The majority of our patients (70.2%) was found to be affected by no other ADs apart from HT, whereas the remaining 29.8% were classified as affected by an APS-3. The ADs which were found most frequently in aggregation with HT were type 1 diabetes mellitus T1DM (61.9%) and celiac disease CD (22.2%). CONCLUSIONS: 1) About 30% of young patients with HT may exhibit a clinical picture consistent with APS-3; 2) In the context of APS-3 the ADs that most frequently cluster with HT are T1DM and CD.
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spelling pubmed-55458412017-08-09 Epidemiological and clinical peculiarities of polyglandular syndrome type 3 in pediatric age Valenzise, Mariella Aversa, Tommaso Saccomanno, Angiola De Luca, Filippo Salzano, Giuseppina Ital J Pediatr Research BACKGROUND: Although the autoimmune polyglandular syndrome type 3 (APS-3) is the commonest APS that may be encountered in pediatric age, last year literature includes only few studies aiming to specifically ascertain the clinical spectrum of APS-3 in childhood and adolescence. Aims of these study were: a) to ascertain how many young patients with apparently isolated Hashimoto’s thyroiditis (HT) are at risk of manifesting other autoimmune disorders (ADs) compatible with APS-3; b) to individuate the ADs which most frequently segregate with HT in the context of an APS-3. METHODS: A selected population of 211 young patients with HT and no risk factors for other APSs was investigated, in order to evaluate the prevalence of other ADs apart from HT and to individuate the ADs which most frequently cluster with HT in the context of APS-3. RESULTS: The majority of our patients (70.2%) was found to be affected by no other ADs apart from HT, whereas the remaining 29.8% were classified as affected by an APS-3. The ADs which were found most frequently in aggregation with HT were type 1 diabetes mellitus T1DM (61.9%) and celiac disease CD (22.2%). CONCLUSIONS: 1) About 30% of young patients with HT may exhibit a clinical picture consistent with APS-3; 2) In the context of APS-3 the ADs that most frequently cluster with HT are T1DM and CD. BioMed Central 2017-08-07 /pmc/articles/PMC5545841/ /pubmed/28784159 http://dx.doi.org/10.1186/s13052-017-0386-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Valenzise, Mariella
Aversa, Tommaso
Saccomanno, Angiola
De Luca, Filippo
Salzano, Giuseppina
Epidemiological and clinical peculiarities of polyglandular syndrome type 3 in pediatric age
title Epidemiological and clinical peculiarities of polyglandular syndrome type 3 in pediatric age
title_full Epidemiological and clinical peculiarities of polyglandular syndrome type 3 in pediatric age
title_fullStr Epidemiological and clinical peculiarities of polyglandular syndrome type 3 in pediatric age
title_full_unstemmed Epidemiological and clinical peculiarities of polyglandular syndrome type 3 in pediatric age
title_short Epidemiological and clinical peculiarities of polyglandular syndrome type 3 in pediatric age
title_sort epidemiological and clinical peculiarities of polyglandular syndrome type 3 in pediatric age
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545841/
https://www.ncbi.nlm.nih.gov/pubmed/28784159
http://dx.doi.org/10.1186/s13052-017-0386-4
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