Cargando…

Prognostic Factors of 30-day Survival of Patients with Malignant Pleural Effusion

BACKGROUND: Treatment of malignant pleural effusion (MPE) depends on the 1 month prognosis of patients. Until now, there is no study evaluate factors affecting 1 month survival. AIMS: This study aims to determine the predictors of survival within 1 month. METHODS: Prospective study of 102 patients w...

Descripción completa

Detalles Bibliográficos
Autores principales: Amin, Zulkifli, Iskandar, Stephen Diah, Sibli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545961/
https://www.ncbi.nlm.nih.gov/pubmed/28827939
http://dx.doi.org/10.4103/IJPC.IJPC_2_17
_version_ 1783255513379635200
author Amin, Zulkifli
Iskandar, Stephen Diah
Sibli,
author_facet Amin, Zulkifli
Iskandar, Stephen Diah
Sibli,
author_sort Amin, Zulkifli
collection PubMed
description BACKGROUND: Treatment of malignant pleural effusion (MPE) depends on the 1 month prognosis of patients. Until now, there is no study evaluate factors affecting 1 month survival. AIMS: This study aims to determine the predictors of survival within 1 month. METHODS: Prospective study of 102 patients with MPE. Biochemistry data of pleural fluid, characteristics of tumor, and massiveness of the effusion were analyzed to determine their effect on 30-day survival of the patients. Univariate analysis was performed using Chi-square. All prognostic factors that had P < 0.25 were included in multivariate analysis using Cox regression. RESULTS: Median age of patients was 51 years, most of them were female (56%). Common primary sites of tumor were lung (31%), breast (19%), and lymphatic tissue (11%). In univariate analysis, factors that have P < 0.25 were low glucose concentration in pleural fluid (P = 0.01), high lactate dehydrogenase concentration in pleural fluid (P = 0.25), and high risk tumor (P = 0.24). In multivariate analysis, only low glucose concentration was significantly related to poor survival within 1 month (hazard ratio 2.85 [1.10–7.61], P = 0.03). CONCLUSIONS: Low level of glucose in pleural fluid is an important factor related to 30-day survival in patients with MPE. It can be used to determine prognosis-based treatment objectively.
format Online
Article
Text
id pubmed-5545961
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-55459612017-08-21 Prognostic Factors of 30-day Survival of Patients with Malignant Pleural Effusion Amin, Zulkifli Iskandar, Stephen Diah Sibli, Indian J Palliat Care Original Article BACKGROUND: Treatment of malignant pleural effusion (MPE) depends on the 1 month prognosis of patients. Until now, there is no study evaluate factors affecting 1 month survival. AIMS: This study aims to determine the predictors of survival within 1 month. METHODS: Prospective study of 102 patients with MPE. Biochemistry data of pleural fluid, characteristics of tumor, and massiveness of the effusion were analyzed to determine their effect on 30-day survival of the patients. Univariate analysis was performed using Chi-square. All prognostic factors that had P < 0.25 were included in multivariate analysis using Cox regression. RESULTS: Median age of patients was 51 years, most of them were female (56%). Common primary sites of tumor were lung (31%), breast (19%), and lymphatic tissue (11%). In univariate analysis, factors that have P < 0.25 were low glucose concentration in pleural fluid (P = 0.01), high lactate dehydrogenase concentration in pleural fluid (P = 0.25), and high risk tumor (P = 0.24). In multivariate analysis, only low glucose concentration was significantly related to poor survival within 1 month (hazard ratio 2.85 [1.10–7.61], P = 0.03). CONCLUSIONS: Low level of glucose in pleural fluid is an important factor related to 30-day survival in patients with MPE. It can be used to determine prognosis-based treatment objectively. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5545961/ /pubmed/28827939 http://dx.doi.org/10.4103/IJPC.IJPC_2_17 Text en Copyright: © 2017 Indian Journal of Palliative Care http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Amin, Zulkifli
Iskandar, Stephen Diah
Sibli,
Prognostic Factors of 30-day Survival of Patients with Malignant Pleural Effusion
title Prognostic Factors of 30-day Survival of Patients with Malignant Pleural Effusion
title_full Prognostic Factors of 30-day Survival of Patients with Malignant Pleural Effusion
title_fullStr Prognostic Factors of 30-day Survival of Patients with Malignant Pleural Effusion
title_full_unstemmed Prognostic Factors of 30-day Survival of Patients with Malignant Pleural Effusion
title_short Prognostic Factors of 30-day Survival of Patients with Malignant Pleural Effusion
title_sort prognostic factors of 30-day survival of patients with malignant pleural effusion
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545961/
https://www.ncbi.nlm.nih.gov/pubmed/28827939
http://dx.doi.org/10.4103/IJPC.IJPC_2_17
work_keys_str_mv AT aminzulkifli prognosticfactorsof30daysurvivalofpatientswithmalignantpleuraleffusion
AT iskandarstephendiah prognosticfactorsof30daysurvivalofpatientswithmalignantpleuraleffusion
AT sibli prognosticfactorsof30daysurvivalofpatientswithmalignantpleuraleffusion