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Engineering the fragment crystallizable (Fc) region of human IgG1 multimers and monomers to fine-tune interactions with sialic acid-dependent receptors

Multimeric fragment crystallizable (Fc) regions and Fc-fusion proteins are actively being explored as biomimetic replacements for IVIG therapy, which is deployed to manage many diseases and conditions but is expensive and not always efficient. The Fc region of human IgG1 (IgG1-Fc) can be engineered...

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Detalles Bibliográficos
Autores principales:	Blundell, Patricia A., Le, Ngoc Phuong Lan, Allen, Joel, Watanabe, Yasunori, Pleass, Richard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546038/ https://www.ncbi.nlm.nih.gov/pubmed/28620050 http://dx.doi.org/10.1074/jbc.M117.795047

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