Modulation of Glutathione Hemostasis by Inhibition of 12/15-Lipoxygenase Prevents ROS-Mediated Cell Death after Hepatic Ischemia and Reperfusion

BACKGROUND: Reactive oxygen species- (ROS-) mediated ischemia-reperfusion injury (IRI) detrimentally impacts liver transplantation and resection. 12/15-Lipoxygenase (12/15-LOX), an antagonistic protein of the glutathione peroxidase 4 (GPX4) signaling cascade, was proven to mediate cell death in post...

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Detalles Bibliográficos
Autores principales: Drefs, Moritz, Thomas, Michael N., Guba, Markus, Angele, Martin K., Werner, Jens, Conrad, Marcus, Steib, Christian J., Holdt, Lesca M., Andrassy, Joachim, Khandoga, Andrej, Rentsch, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546123/
https://www.ncbi.nlm.nih.gov/pubmed/28811867
http://dx.doi.org/10.1155/2017/8325754

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