Cargando…

Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress

The proteasome inhibitor bortezomib has proven to be invaluable in the treatment of myeloma. By exploiting the inherent high immunoglobulin protein production of malignant plasma cells, bortezomib induces endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), resulting in myeloma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wallington-Beddoe, Craig T., Bennett, Melissa K., Vandyke, Kate, Davies, Lorena, Zebol, Julia R., Moretti, Paul A.B., Pitman, Melissa R., Hewett, Duncan R., Zannettino, Andrew C.W., Pitson, Stuart M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546428/ https://www.ncbi.nlm.nih.gov/pubmed/28467788 http://dx.doi.org/10.18632/oncotarget.17115

Ejemplares similares

An oncogenic role for sphingosine kinase 2
por: Neubauer, Heidi A., et al.
Publicado: (2016)

A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties
por: Pitman, Melissa R., et al.
Publicado: (2015)

Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition
por: Bennett, Melissa K., et al.
Publicado: (2021)

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
por: Pitson, Stuart M., et al.
Publicado: (2005)

Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma
por: Neubauer, Heidi A., et al.
Publicado: (2018)

The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism
por: Pitman, Melissa R., et al.
Publicado: (2022)

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells
por: McNaughton, Melissa, et al.
Publicado: (2016)

Enhancing ER stress in myeloma
por: Wallington-Beddoe, Craig T., et al.
Publicado: (2017)

Novel therapies for multiple myeloma
por: Wallington-Beddoe, Craig T., et al.
Publicado: (2017)

Synergise or perish
por: Grover, Harpreet Singh
Publicado: (2021)

Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1α/XBP1 pathway
por: Namba, Takushi, et al.
Publicado: (2015)

BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells
por: Baker, Emma K, et al.
Publicado: (2015)

LCRF‐0006, a small molecule mimetic of the N‐cadherin antagonist peptide ADH‐1, synergistically increases multiple myeloma response to bortezomib
por: Mrozik, Krzysztof M., et al.
Publicado: (2020)

SAMSN1 Is a Tumor Suppressor Gene in Multiple Myeloma()()
por: Noll, Jacqueline E., et al.
Publicado: (2014)

Desmoglein‐2 expression is an independent predictor of poor prognosis patients with multiple myeloma
por: Ebert, Lisa M., et al.
Publicado: (2021)

CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1
por: Zhu, Wenying, et al.
Publicado: (2016)

Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice
por: Xie, Vicki, et al.
Publicado: (2018)

Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies
por: Lewis, Alexander C., et al.
Publicado: (2018)

Author Correction: Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies
por: Lewis, Alexander C., et al.
Publicado: (2021)

Characterization of the role of Samsn1 loss in multiple myeloma development
por: Friend, Natasha L., et al.
Publicado: (2020)

Expression of the chemokine receptor CCR1 promotes the dissemination of multiple myeloma plasma cells in vivo
por: Zeissig, Mara N., et al.
Publicado: (2020)

α-Tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells
por: Tomasetti, M, et al.
Publicado: (2004)

PTTG1 expression is associated with hyperproliferative disease and poor prognosis in multiple myeloma
por: Noll, Jacqueline E., et al.
Publicado: (2015)

DNA Barcoding Reveals Habitual Clonal Dominance of Myeloma Plasma Cells in the Bone Marrow Microenvironment
por: Hewett, Duncan R., et al.
Publicado: (2017)

Bortezomib initiates endoplasmic reticulum stress, elicits autophagy and death in Echinococcus granulosus larval stage
por: Nicolao, María Celeste, et al.
Publicado: (2017)

Comparison of SARS-CoV-2 RT-PCR on a high-throughput molecular diagnostic platform and the cobas SARS-CoV-2 test for the diagnostic of COVID-19 on various clinical samples
por: Opota, Onya, et al.
Publicado: (2020)

Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase
por: Di Gennaro, E, et al.
Publicado: (2010)

MYCN and mutationally activated ALK synergise in neuroblastoma
Publicado: (2012)

Panobinostat synergizes with bortezomib to induce endoplasmic reticulum stress and ubiquitinated protein accumulation in renal cancer cells
por: Sato, Akinori, et al.
Publicado: (2014)

Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo
por: Benvenuto, Monica, et al.
Publicado: (2023)

The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells
por: Limaye, Vidya, et al.
Publicado: (2009)

THE ENDOPLASMIC RETICULUM
por: Palade, George E.
Publicado: (1956)

Using genomics to better define high-risk MGUS/SMM patients
por: Dutta, Ankit K., et al.
Publicado: (2018)

Correction: Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir–bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death
por: Johnson, Charlotte E., et al.
Publicado: (2019)

Common Germline Risk Variants Impact Somatic Alterations and Clinical Features across Cancers
por: Namba, Shinichi, et al.
Publicado: (2023)

Occupational heat stress in Australian workplaces
por: Jay, Ollie, et al.
Publicado: (2016)

Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells
por: MORIYA, SHOTA, et al.
Publicado: (2013)

Lercanidipine Synergistically Enhances Bortezomib Cytotoxicity in Cancer Cells via Enhanced Endoplasmic Reticulum Stress and Mitochondrial Ca(2+) Overload
por: Lee, A Reum, et al.
Publicado: (2019)

The tyrosine kinase inhibitor dasatinib (SPRYCEL) inhibits chondrocyte activity and proliferation
por: Vandyke, K, et al.
Publicado: (2011)

Validation of commercially available sphingosine kinase 2 antibodies for use in immunoblotting, immunoprecipitation and immunofluorescence
por: Neubauer, Heidi A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_irb7qf29eg5uabe1kson3u05m9