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Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature
Recently developed potent and selective CDK4/6 inhibitors fall into two classes based on structure and toxicity profiles in clinical studies. One class, exemplified by palbociclib and ribociclib, exhibits neutropenia as a dose-limiting toxicity and requires discontinuous dosing. In contrast, the str...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546433/ https://www.ncbi.nlm.nih.gov/pubmed/28620137 http://dx.doi.org/10.18632/oncotarget.18435 |