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IRF5 is associated with adverse postoperative prognosis of patients with non-metastatic clear cell renal cell carcinoma

BACKGROUND: IRF5 is one member of IRFs family, and is critical for host immunity and cell response. In the present study, we sought to search the clinical and prognostic value of IFR5 in patients with non-metastatic ccRCC. RESULTS: IRF5 proved to be an adverse independent prognostic factor for overa...

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Autores principales: Bai, Qi, Liu, Li, Xia, Yu, Wang, Jiajun, Xi, Wei, Qu, Yang, Xiong, Ying, Long, Qilai, Xu, Jiejie, Guo, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546472/
https://www.ncbi.nlm.nih.gov/pubmed/28562332
http://dx.doi.org/10.18632/oncotarget.17777
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author Bai, Qi
Liu, Li
Xia, Yu
Wang, Jiajun
Xi, Wei
Qu, Yang
Xiong, Ying
Long, Qilai
Xu, Jiejie
Guo, Jianming
author_facet Bai, Qi
Liu, Li
Xia, Yu
Wang, Jiajun
Xi, Wei
Qu, Yang
Xiong, Ying
Long, Qilai
Xu, Jiejie
Guo, Jianming
author_sort Bai, Qi
collection PubMed
description BACKGROUND: IRF5 is one member of IRFs family, and is critical for host immunity and cell response. In the present study, we sought to search the clinical and prognostic value of IFR5 in patients with non-metastatic ccRCC. RESULTS: IRF5 proved to be an adverse independent prognostic factor for overall survival (p < 0.001) and recurrence free survival (p = 0.002). The newly built nomograms could give better prediction for overall survival and recurrence free survival in ccRCC patients. MATERIALS AND METHODS: We included 264 individuals who were diagnosed with non-metastatic clear cell renal cell carcinoma in the present study. Immunohistochemistry staining was performed on tissue microarrays to evaluate the IRF5 expression. χ(2) test, Fisher's exact test, t test, Kaplan-Meier method and Cox proportional hazard model were applied to evaluate the prognostic value of IRF5. Two nomograms were constructed to predict clinical outcomes for ccRCC patients after surgery. CONCLUSIONS: IRF5 was an adverse independent prognostic factor for both overall survival and recurrence free survival in patients with non-metastatic ccRCC.
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spelling pubmed-55464722017-08-23 IRF5 is associated with adverse postoperative prognosis of patients with non-metastatic clear cell renal cell carcinoma Bai, Qi Liu, Li Xia, Yu Wang, Jiajun Xi, Wei Qu, Yang Xiong, Ying Long, Qilai Xu, Jiejie Guo, Jianming Oncotarget Research Paper BACKGROUND: IRF5 is one member of IRFs family, and is critical for host immunity and cell response. In the present study, we sought to search the clinical and prognostic value of IFR5 in patients with non-metastatic ccRCC. RESULTS: IRF5 proved to be an adverse independent prognostic factor for overall survival (p < 0.001) and recurrence free survival (p = 0.002). The newly built nomograms could give better prediction for overall survival and recurrence free survival in ccRCC patients. MATERIALS AND METHODS: We included 264 individuals who were diagnosed with non-metastatic clear cell renal cell carcinoma in the present study. Immunohistochemistry staining was performed on tissue microarrays to evaluate the IRF5 expression. χ(2) test, Fisher's exact test, t test, Kaplan-Meier method and Cox proportional hazard model were applied to evaluate the prognostic value of IRF5. Two nomograms were constructed to predict clinical outcomes for ccRCC patients after surgery. CONCLUSIONS: IRF5 was an adverse independent prognostic factor for both overall survival and recurrence free survival in patients with non-metastatic ccRCC. Impact Journals LLC 2017-05-11 /pmc/articles/PMC5546472/ /pubmed/28562332 http://dx.doi.org/10.18632/oncotarget.17777 Text en Copyright: © 2017 Bai et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Bai, Qi
Liu, Li
Xia, Yu
Wang, Jiajun
Xi, Wei
Qu, Yang
Xiong, Ying
Long, Qilai
Xu, Jiejie
Guo, Jianming
IRF5 is associated with adverse postoperative prognosis of patients with non-metastatic clear cell renal cell carcinoma
title IRF5 is associated with adverse postoperative prognosis of patients with non-metastatic clear cell renal cell carcinoma
title_full IRF5 is associated with adverse postoperative prognosis of patients with non-metastatic clear cell renal cell carcinoma
title_fullStr IRF5 is associated with adverse postoperative prognosis of patients with non-metastatic clear cell renal cell carcinoma
title_full_unstemmed IRF5 is associated with adverse postoperative prognosis of patients with non-metastatic clear cell renal cell carcinoma
title_short IRF5 is associated with adverse postoperative prognosis of patients with non-metastatic clear cell renal cell carcinoma
title_sort irf5 is associated with adverse postoperative prognosis of patients with non-metastatic clear cell renal cell carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546472/
https://www.ncbi.nlm.nih.gov/pubmed/28562332
http://dx.doi.org/10.18632/oncotarget.17777
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