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DDX11-AS1 as potential therapy targets for human hepatocellular carcinoma

Hepatocellular Carcinoma (HCC) is one of the most fatal cancers, whose incidence and death rates are still rising. Here, we report the identification of long non-coding RNAs (IncRNAs) that associated with HCC progression and metabolism based on the systematically analysis of large scale RNA-seq data...

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Autores principales: Shi, Min, Zhang, Xiao-Yu, Yu, Heguo, Xiang, Shi-Hao, Xu, Ling, Wei, Jue, Wu, Qiong, Jia, Rongrong, Wang, Yu-Gang, Lu, Xiao-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546473/
https://www.ncbi.nlm.nih.gov/pubmed/28496001
http://dx.doi.org/10.18632/oncotarget.17409
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author Shi, Min
Zhang, Xiao-Yu
Yu, Heguo
Xiang, Shi-Hao
Xu, Ling
Wei, Jue
Wu, Qiong
Jia, Rongrong
Wang, Yu-Gang
Lu, Xiao-Jie
author_facet Shi, Min
Zhang, Xiao-Yu
Yu, Heguo
Xiang, Shi-Hao
Xu, Ling
Wei, Jue
Wu, Qiong
Jia, Rongrong
Wang, Yu-Gang
Lu, Xiao-Jie
author_sort Shi, Min
collection PubMed
description Hepatocellular Carcinoma (HCC) is one of the most fatal cancers, whose incidence and death rates are still rising. Here, we report the identification of long non-coding RNAs (IncRNAs) that associated with HCC progression and metabolism based on the systematically analysis of large scale RNA-seq data from HCC patients. We identified seven lncRNAs with high confidence which were highly related with prognostic of HCC. Of note, three of them had quite different expression patterns between the control samples and the patients, and their critical roles in cancer progression were validated. We proposed that DDX11-AS1 play important role during HCC oncogenesis and may serve as potential therapy target for HCC.
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spelling pubmed-55464732017-08-23 DDX11-AS1 as potential therapy targets for human hepatocellular carcinoma Shi, Min Zhang, Xiao-Yu Yu, Heguo Xiang, Shi-Hao Xu, Ling Wei, Jue Wu, Qiong Jia, Rongrong Wang, Yu-Gang Lu, Xiao-Jie Oncotarget Research Paper Hepatocellular Carcinoma (HCC) is one of the most fatal cancers, whose incidence and death rates are still rising. Here, we report the identification of long non-coding RNAs (IncRNAs) that associated with HCC progression and metabolism based on the systematically analysis of large scale RNA-seq data from HCC patients. We identified seven lncRNAs with high confidence which were highly related with prognostic of HCC. Of note, three of them had quite different expression patterns between the control samples and the patients, and their critical roles in cancer progression were validated. We proposed that DDX11-AS1 play important role during HCC oncogenesis and may serve as potential therapy target for HCC. Impact Journals LLC 2017-04-25 /pmc/articles/PMC5546473/ /pubmed/28496001 http://dx.doi.org/10.18632/oncotarget.17409 Text en Copyright: © 2017 Shi et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Shi, Min
Zhang, Xiao-Yu
Yu, Heguo
Xiang, Shi-Hao
Xu, Ling
Wei, Jue
Wu, Qiong
Jia, Rongrong
Wang, Yu-Gang
Lu, Xiao-Jie
DDX11-AS1 as potential therapy targets for human hepatocellular carcinoma
title DDX11-AS1 as potential therapy targets for human hepatocellular carcinoma
title_full DDX11-AS1 as potential therapy targets for human hepatocellular carcinoma
title_fullStr DDX11-AS1 as potential therapy targets for human hepatocellular carcinoma
title_full_unstemmed DDX11-AS1 as potential therapy targets for human hepatocellular carcinoma
title_short DDX11-AS1 as potential therapy targets for human hepatocellular carcinoma
title_sort ddx11-as1 as potential therapy targets for human hepatocellular carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546473/
https://www.ncbi.nlm.nih.gov/pubmed/28496001
http://dx.doi.org/10.18632/oncotarget.17409
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