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Synergistic targeting of malignant pleural mesothelioma cells by MDM2 inhibitors and TRAIL agonists

Malignant Pleural Mesothelioma (MPM) is a chemoresistant tumor characterized by low rate of p53 mutation and upregulation of Murine Double Minute 2 (MDM2), suggesting that it may be effectively targeted using MDM2 inhibitors. In the present study, we investigated the anticancer activity of the MDM2...

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Detalles Bibliográficos
Autores principales:	Urso, Loredana, Cavallari, Ilaria, Silic-Benussi, Micol, Biasini, Lorena, Zago, Giulia, Calabrese, Fiorella, Conte, Pier Franco, Ciminale, Vincenzo, Pasello, Giulia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546476/ https://www.ncbi.nlm.nih.gov/pubmed/28562336 http://dx.doi.org/10.18632/oncotarget.17790

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