Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG

Whether vitamin D is chemopreventive and/or has potential therapeutically in prostate cancer is unresolved. One confounding factor is that many prostate cancers express a TMPRSS2:ERG fusion gene whose expression is increased both by androgens and by vitamin D receptor (VDR) activation. Two challenge...

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Detalles Bibliográficos
Autores principales: Roberts, Justin M., Martin, Rebeca San, Badrajee, D. Piyarathna, MacKrell, James G., Rocha, Guilherme V., Dodge, Jeffery A., Coarfa, Cristian, Krishnan, Venkatesh, Rowley, David R., Weigel, Nancy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546493/
https://www.ncbi.nlm.nih.gov/pubmed/28591703
http://dx.doi.org/10.18632/oncotarget.17968

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