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Interleukin-6-174G>C gene promoter polymorphism and prognosis in patients with cancer

Interleukin-6 (IL-6) is known to be involved in the pathogenesis of cancer progression. IL-6-174G>C polymorphism has shown several results in association studies. In this study, we evaluated the association the IL-6-174G>C polymorphism and overall survival (OS) of cancer using 17 eligible stud...

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Autores principales: Zhai, Kan, Yang, Yong, Gao, Zhi-Gang, Ding, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546496/
https://www.ncbi.nlm.nih.gov/pubmed/28548958
http://dx.doi.org/10.18632/oncotarget.17771
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author Zhai, Kan
Yang, Yong
Gao, Zhi-Gang
Ding, Jie
author_facet Zhai, Kan
Yang, Yong
Gao, Zhi-Gang
Ding, Jie
author_sort Zhai, Kan
collection PubMed
description Interleukin-6 (IL-6) is known to be involved in the pathogenesis of cancer progression. IL-6-174G>C polymorphism has shown several results in association studies. In this study, we evaluated the association the IL-6-174G>C polymorphism and overall survival (OS) of cancer using 17 eligible studies with 4,304 patients. Our meta-analysis indicated that IL-6-174G>C polymorphism is not associated with OS when assessed using 3 genotype comparison including GG/(GC+CC), CC/(GC+GG) and CC/GG. Interestingly, compared to GG carrier, patients with IL-6-174GC genotype showed a decreased hazard of poor OS (hazard ratio = 0.81, 95% confidence interval: 0.68–0.96, P = 0.018; I(2) = 34.5%, Phet = 0.107). However, for GG/(GC+CC) genotype comparison, this SNP is affect patients’ OS obviously in bladder cancer, ovarian and peritoneal cancer, neuroblastoma, gastric cancer and osteosarcoma, though pooled results showing negative association because adverse and protective effect on different type of cancer balance each other. These results suggest IL-6-174G>C polymorphism might play a role in modulating OS in different type of cancer and might contribute to individual treatment in the future.
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spelling pubmed-55464962017-08-23 Interleukin-6-174G>C gene promoter polymorphism and prognosis in patients with cancer Zhai, Kan Yang, Yong Gao, Zhi-Gang Ding, Jie Oncotarget Research Paper Interleukin-6 (IL-6) is known to be involved in the pathogenesis of cancer progression. IL-6-174G>C polymorphism has shown several results in association studies. In this study, we evaluated the association the IL-6-174G>C polymorphism and overall survival (OS) of cancer using 17 eligible studies with 4,304 patients. Our meta-analysis indicated that IL-6-174G>C polymorphism is not associated with OS when assessed using 3 genotype comparison including GG/(GC+CC), CC/(GC+GG) and CC/GG. Interestingly, compared to GG carrier, patients with IL-6-174GC genotype showed a decreased hazard of poor OS (hazard ratio = 0.81, 95% confidence interval: 0.68–0.96, P = 0.018; I(2) = 34.5%, Phet = 0.107). However, for GG/(GC+CC) genotype comparison, this SNP is affect patients’ OS obviously in bladder cancer, ovarian and peritoneal cancer, neuroblastoma, gastric cancer and osteosarcoma, though pooled results showing negative association because adverse and protective effect on different type of cancer balance each other. These results suggest IL-6-174G>C polymorphism might play a role in modulating OS in different type of cancer and might contribute to individual treatment in the future. Impact Journals LLC 2017-05-10 /pmc/articles/PMC5546496/ /pubmed/28548958 http://dx.doi.org/10.18632/oncotarget.17771 Text en Copyright: © 2017 Zhai et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhai, Kan
Yang, Yong
Gao, Zhi-Gang
Ding, Jie
Interleukin-6-174G>C gene promoter polymorphism and prognosis in patients with cancer
title Interleukin-6-174G>C gene promoter polymorphism and prognosis in patients with cancer
title_full Interleukin-6-174G>C gene promoter polymorphism and prognosis in patients with cancer
title_fullStr Interleukin-6-174G>C gene promoter polymorphism and prognosis in patients with cancer
title_full_unstemmed Interleukin-6-174G>C gene promoter polymorphism and prognosis in patients with cancer
title_short Interleukin-6-174G>C gene promoter polymorphism and prognosis in patients with cancer
title_sort interleukin-6-174g>c gene promoter polymorphism and prognosis in patients with cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546496/
https://www.ncbi.nlm.nih.gov/pubmed/28548958
http://dx.doi.org/10.18632/oncotarget.17771
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