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The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination
Hyperthermia has a number of biological effects that sensitize tumors to radiotherapy in the range between 40-44 °C. One of these effects is heat-induced degradation of BRCA2 that in turn causes reduced RAD51 focus formation, which results in an attenuation of DNA repair through homologous recombina...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546504/ https://www.ncbi.nlm.nih.gov/pubmed/28574821 http://dx.doi.org/10.18632/oncotarget.17861 |