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BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity

Neoplastic cells in pancreatic ductual adenocarcinoma (PDAC) survive in an energy-deprived milieu, and hyper-activation of Akt is thought to contribute to the neoplastic cell survival in PDAC. Kras activating mutations, common in PDAC, was believed to be the major driver of Akt activation. However,...

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Detalles Bibliográficos
Autores principales:	Saiyin, Hexige, Na, Ning, Han, Xu, Fang, Yuan, Wu, Yanhua, Lou, Wenhui, Yang, Xianmei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546509/ https://www.ncbi.nlm.nih.gov/pubmed/28591720 http://dx.doi.org/10.18632/oncotarget.17965

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