Deregulation of the non-coding genome in leukemia

Methodological advances that allow deeper characterization of non-coding elements in the genome have started to reveal the full spectrum of deregulation in cancer. We generated an inducible cell model to track transcriptional changes after induction of a well-known leukemia-inducing fusion gene, ETV...

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Autores principales: Teppo, Susanna, Heinäniemi, Merja, Lohi, Olli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546539/
https://www.ncbi.nlm.nih.gov/pubmed/28387584
http://dx.doi.org/10.1080/15476286.2017.1312228
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author Teppo, Susanna
Heinäniemi, Merja
Lohi, Olli
author_facet Teppo, Susanna
Heinäniemi, Merja
Lohi, Olli
author_sort Teppo, Susanna
collection PubMed
description Methodological advances that allow deeper characterization of non-coding elements in the genome have started to reveal the full spectrum of deregulation in cancer. We generated an inducible cell model to track transcriptional changes after induction of a well-known leukemia-inducing fusion gene, ETV6-RUNX1. Our data revealed widespread transcriptional alterations outside coding elements in the genome. This adds to the growing list of various alterations in the non-coding genome in cancer and pinpoints their role in diseased cellular state.
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spelling pubmed-55465392017-08-15 Deregulation of the non-coding genome in leukemia Teppo, Susanna Heinäniemi, Merja Lohi, Olli RNA Biol Point of View Methodological advances that allow deeper characterization of non-coding elements in the genome have started to reveal the full spectrum of deregulation in cancer. We generated an inducible cell model to track transcriptional changes after induction of a well-known leukemia-inducing fusion gene, ETV6-RUNX1. Our data revealed widespread transcriptional alterations outside coding elements in the genome. This adds to the growing list of various alterations in the non-coding genome in cancer and pinpoints their role in diseased cellular state. Taylor & Francis 2017-04-07 /pmc/articles/PMC5546539/ /pubmed/28387584 http://dx.doi.org/10.1080/15476286.2017.1312228 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Point of View
Teppo, Susanna
Heinäniemi, Merja
Lohi, Olli
Deregulation of the non-coding genome in leukemia
title Deregulation of the non-coding genome in leukemia
title_full Deregulation of the non-coding genome in leukemia
title_fullStr Deregulation of the non-coding genome in leukemia
title_full_unstemmed Deregulation of the non-coding genome in leukemia
title_short Deregulation of the non-coding genome in leukemia
title_sort deregulation of the non-coding genome in leukemia
topic Point of View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546539/
https://www.ncbi.nlm.nih.gov/pubmed/28387584
http://dx.doi.org/10.1080/15476286.2017.1312228
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AT heinaniemimerja deregulationofthenoncodinggenomeinleukemia
AT lohiolli deregulationofthenoncodinggenomeinleukemia

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