An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein

Prion diseases are neurodegenerative conditions characterized by the conformational conversion of the cellular prion protein (PrP(C)), an endogenous membrane glycoprotein of uncertain function, into PrP(Sc), a pathological isoform that replicates by imposing its abnormal folding onto PrP(C) molecule...

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Detalles Bibliográficos
Autores principales: Stincardini, Claudia, Massignan, Tania, Biggi, Silvia, Elezgarai, Saioa R., Sangiovanni, Valeria, Vanni, Ilaria, Pancher, Michael, Adami, Valentina, Moreno, Jorge, Stravalaci, Matteo, Maietta, Giulia, Gobbi, Marco, Negro, Alessandro, Requena, Jesús R., Castilla, Joaquín, Nonno, Romolo, Biasini, Emiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546605/
https://www.ncbi.nlm.nih.gov/pubmed/28787011
http://dx.doi.org/10.1371/journal.pone.0182589

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