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Effects of nanosilver and nanozinc incorporated mesoporous calcium-silicate nanoparticles on the mechanical properties of dentin

Mesoporous calcium-silicate nanoparticles (MCSNs) are advanced biomaterials for drug delivery and mineralization induction. They can load silver and exhibit significantly antibacterial effects. However, the effects of MCSNs and silver-loaded MCSNs on dentin are unknown. The silver (Ag) and/or zinc (...

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Autores principales: Zhu, Jie, Liang, Ruizhen, Sun, Chao, Xie, Lizhe, Wang, Juan, Leng, Diya, Wu, Daming, Liu, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546636/
https://www.ncbi.nlm.nih.gov/pubmed/28787004
http://dx.doi.org/10.1371/journal.pone.0182583
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author Zhu, Jie
Liang, Ruizhen
Sun, Chao
Xie, Lizhe
Wang, Juan
Leng, Diya
Wu, Daming
Liu, Weihong
author_facet Zhu, Jie
Liang, Ruizhen
Sun, Chao
Xie, Lizhe
Wang, Juan
Leng, Diya
Wu, Daming
Liu, Weihong
author_sort Zhu, Jie
collection PubMed
description Mesoporous calcium-silicate nanoparticles (MCSNs) are advanced biomaterials for drug delivery and mineralization induction. They can load silver and exhibit significantly antibacterial effects. However, the effects of MCSNs and silver-loaded MCSNs on dentin are unknown. The silver (Ag) and/or zinc (Zn) incorporated MCSNs (Ag-Zn-MCSNs) were prepared by a template method, and their characterizations were tested. Then the nanoparticles were filled into root canals and their effects on the dentin were investigated. Ag-Zn-MCSNs showed characteristics of mesoporous materials and sustained release of ions over time. Ag-Zn-MCSNs adhered well to the root canal walls and infiltrated into the dentinal tubules after ultrasound activation. Ag-Zn-MCSNs showed no significantly negative effects on either the flexural strength or the modulus of elasticity of dentin, while CH decreased the flexural strength of dentin significantly (P<0.05). These findings suggested that Ag and Zn can be incorporated into MCSNs using a template method, and the Ag-Zn-MCSNs may be developed into a new disinfectant for the root canal and dentinal tubules.
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spelling pubmed-55466362017-08-12 Effects of nanosilver and nanozinc incorporated mesoporous calcium-silicate nanoparticles on the mechanical properties of dentin Zhu, Jie Liang, Ruizhen Sun, Chao Xie, Lizhe Wang, Juan Leng, Diya Wu, Daming Liu, Weihong PLoS One Research Article Mesoporous calcium-silicate nanoparticles (MCSNs) are advanced biomaterials for drug delivery and mineralization induction. They can load silver and exhibit significantly antibacterial effects. However, the effects of MCSNs and silver-loaded MCSNs on dentin are unknown. The silver (Ag) and/or zinc (Zn) incorporated MCSNs (Ag-Zn-MCSNs) were prepared by a template method, and their characterizations were tested. Then the nanoparticles were filled into root canals and their effects on the dentin were investigated. Ag-Zn-MCSNs showed characteristics of mesoporous materials and sustained release of ions over time. Ag-Zn-MCSNs adhered well to the root canal walls and infiltrated into the dentinal tubules after ultrasound activation. Ag-Zn-MCSNs showed no significantly negative effects on either the flexural strength or the modulus of elasticity of dentin, while CH decreased the flexural strength of dentin significantly (P<0.05). These findings suggested that Ag and Zn can be incorporated into MCSNs using a template method, and the Ag-Zn-MCSNs may be developed into a new disinfectant for the root canal and dentinal tubules. Public Library of Science 2017-08-07 /pmc/articles/PMC5546636/ /pubmed/28787004 http://dx.doi.org/10.1371/journal.pone.0182583 Text en © 2017 Zhu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhu, Jie
Liang, Ruizhen
Sun, Chao
Xie, Lizhe
Wang, Juan
Leng, Diya
Wu, Daming
Liu, Weihong
Effects of nanosilver and nanozinc incorporated mesoporous calcium-silicate nanoparticles on the mechanical properties of dentin
title Effects of nanosilver and nanozinc incorporated mesoporous calcium-silicate nanoparticles on the mechanical properties of dentin
title_full Effects of nanosilver and nanozinc incorporated mesoporous calcium-silicate nanoparticles on the mechanical properties of dentin
title_fullStr Effects of nanosilver and nanozinc incorporated mesoporous calcium-silicate nanoparticles on the mechanical properties of dentin
title_full_unstemmed Effects of nanosilver and nanozinc incorporated mesoporous calcium-silicate nanoparticles on the mechanical properties of dentin
title_short Effects of nanosilver and nanozinc incorporated mesoporous calcium-silicate nanoparticles on the mechanical properties of dentin
title_sort effects of nanosilver and nanozinc incorporated mesoporous calcium-silicate nanoparticles on the mechanical properties of dentin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546636/
https://www.ncbi.nlm.nih.gov/pubmed/28787004
http://dx.doi.org/10.1371/journal.pone.0182583
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